| |  Online-Ressource |
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| Verfasst von: | Swoboda, Stefanie [VerfasserIn]  |
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| | Grüttner, Joachim [VerfasserIn] |
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| | Lang, Siegfried [VerfasserIn] |
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| | Wendel, Hans-Peter [VerfasserIn] |
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| | Beyer, Martin E. [VerfasserIn] |
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| | Griesel, Eva [VerfasserIn] |
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| | Hoffmeister, Hans-Martin [VerfasserIn] |
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| | Walter, Thomas [VerfasserIn] |
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| Titel: | Hypothermia inhibits expression of CD11b (MAC-1) and CD162 (PSGL-1) on monocytes during extracorporeal circulation |
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| Verf.angabe: | Stefanie Swoboda, Joachim Gruettner, Siegfried Lang, Hans-Peter Wendel, Martin E. Beyer, Eva Griesel, Hans-Martin Hoffmeister, and Thomas Walter |
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| E-Jahr: | 2013 |
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| Jahr: | June 30, 2013 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 27.01.2022 |
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| Titel Quelle: | Enthalten in: In vivo |
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| Ort Quelle: | Kapandriti, Attiki : IIAR, 2004 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 27(2013), 4, Seite 459-464 |
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| ISSN Quelle: | 1791-7549 |
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| Abstract: | Aim: The aim of the present study was to investigate the effect of different hypothermic temperatures on the expression of cellular adhesion molecules on leukocytes. Materials and Methods: Circulation of blood from six volunteers was performed in an extracorporeal circulation model at 36°C, 28°C and 18°C for 30 minutes. Expression of CD11b, CD54 and CD162 on monocytes was measured using flow cytometry. Results: Expression of CD11b significantly decreased at 18°C and at 28°C compared to 36°C. A significant reduction of CD162 expression was found at 18°C compared to 28°C and 36°C and at 28°C compared to 36°C. No association was found between temperature and expression of CD54. Conclusion: Expression of CD11b and CD162 on monocytes has a temperature-dependent regulation, with decreased expression during hypothermia, which may result in an inhibition of leukocyte-endothelial and leukocyte-platelet interaction. This beneficial effect may influence the extracorporeal circulation-related inflammatory response and tissue damage. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://iv.iiarjournals.org/content/27/4/459 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Hypothermia inhibits expression of CD11b (MAC-1) and CD162 (PSGL-1) on monocytes during extracorporeal circulation. - 2013 |
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| Sach-SW: | cardiopulmonary bypass |
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| | CD11b |
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| | CD162 |
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| | CD54 |
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| | extracorporeal circulation |
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| | hypothermia |
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| | PSGL-1 |
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| K10plus-PPN: | 1787315479 |
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| Verknüpfungen: | → Zeitschrift |
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Hypothermia inhibits expression of CD11b (MAC-1) and CD162 (PSGL-1) on monocytes during extracorporeal circulation / Swoboda, Stefanie [VerfasserIn]; June 30, 2013 (Online-Ressource)
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