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Verfasst von:Rolfs, Arndt [VerfasserIn]   i
 Lichy, Christoph [VerfasserIn]   i
 Hennerici, Michael G. [VerfasserIn]   i
 Fazekas, Franz [VerfasserIn]   i
 Grittner, Ulrike [VerfasserIn]   i
 Dichgans, Martin [VerfasserIn]   i
 Martus, Peter [VerfasserIn]   i
 Holzhausen, Martin [VerfasserIn]   i
 Böttcher, Tobias [VerfasserIn]   i
 Heuschmann, Peter U. [VerfasserIn]   i
 Tatlisumak, Turgut [VerfasserIn]   i
 Tanislav, Christian [VerfasserIn]   i
 Jungehulsing, Gerhard J. [VerfasserIn]   i
 Giese, Anne-Katrin [VerfasserIn]   i
 Putaala, Jukaa [VerfasserIn]   i
 Huber, Roman [VerfasserIn]   i
 Bodechtel, Ulf [VerfasserIn]   i
 Enzinger, Christian [VerfasserIn]   i
 Schmidt, Reinhold [VerfasserIn]   i
 Kaps, Manfred [VerfasserIn]   i
 Kessler, Christof [VerfasserIn]   i
 Lackner, Karl [VerfasserIn]   i
 Paschke, Eduard [VerfasserIn]   i
 Meyer, Wolfgang [VerfasserIn]   i
 Mascher, Hermann [VerfasserIn]   i
 Riess, Olaf [VerfasserIn]   i
 Kolodny, Edwin [VerfasserIn]   i
 Norrving, Bo [VerfasserIn]   i
Titel:Acute cerebrovascular disease in the young
Titelzusatz:the Stroke in Young Fabry Patients Study
Verf.angabe:Arndt Rolfs, MD; Franz Fazekas, MD; Ulrike Grittner, PhD; Martin Dichgans, MD; Peter Martus, PhD; Martin Holzhausen, PhD; Tobias Böttcher, MD; Peter U. Heuschmann, MD; Turgut Tatlisumak, MD; Christian Tanislav, MD; Gerhard J. Jungehulsing, MD; Anne-Katrin Giese, MD; Jukaa Putaala, MD; Roman Huber, MD; Ulf Bodechtel, MD; Christoph Lichy, MD; Christian Enzinger, MD; Reinhold Schmidt, MD; Michael G. Hennerici, MD; Manfred Kaps, MD; Christof Kessler, MD; Karl Lackner, PhD; Eduard Paschke, PhD; Wolfgang Meyer, MD; Hermann Mascher, BSc; Olaf Riess, MD; Edwin Kolodny, MD; Bo Norrving, MD; on behalf of The Stroke in Young Fabry Patients (sifap) investigators
E-Jahr:2013
Jahr:10 Jan 2013
Umfang:10 S.
Fussnoten:Frontdoor und epub nennen 322 Autoren, pdf 28 ; Gesehen am 02.02.2022
Titel Quelle:Enthalten in: Stroke
Ort Quelle:New York, NY : Association, 1970
Jahr Quelle:2013
Band/Heft Quelle:44(2013), 2 vom: Feb., Seite 340-349
ISSN Quelle:1524-4628
Abstract:Background and Purpose — Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease in young adults. Although risk factors and manifestation of atherosclerosis are commonly associated with stroke in the elderly, recent data suggests different causes for stroke in the young. We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients. Methods — Overall, 5023 patients aged 18 to 55 years with the diagnosis of ischemic stroke (3396), hemorrhagic stroke (271), transient ischemic attack (1071) were enrolled in 15 European countries and 47 centers between April 2007 and January 2010 undergoing a detailed, standardized, clinical, laboratory, and radiological protocol. Results — Median age in the overall cohort was 46 years. Definite Fabry disease was diagnosed in 0.5% (95% confidence interval, 0.4%-0.8%; n=27) of all patients; and probable Fabry disease in additional 18 patients. Males dominated the study population (2962/59%) whereas females outnumbered men (65.3%) among the youngest patients (18-24 years). About 80.5% of the patients had a first stroke. Silent infarcts on magnetic resonance imaging were seen in 20% of patients with a first-ever stroke, and in 11.4% of patients with transient ischemic attack and no history of a previous cerebrovascular event. The most common causes of ischemic stroke were large artery atherosclerosis (18.6%) and dissection (9.9%). Conclusions — Definite Fabry disease occurs in 0.5% and probable Fabry disease in further 0.4% of young stroke patients. Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies. Clinical Trial Registration Information — URL: http://www.clinicaltrials.gov.Unique identifier: NCT00414583
DOI:doi:10.1161/STROKEAHA.112.663708
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1161/STROKEAHA.112.663708
 Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.112.663708
 DOI: https://doi.org/10.1161/STROKEAHA.112.663708
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cause
 Fabry disease
 imaging
 intracerebral hemorrhage
 ischemic stroke
 risk factors
 transient ischemic attack
 young stroke
K10plus-PPN:1788309472
Verknüpfungen:→ Zeitschrift

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