| |  Online-Ressource |
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| Verfasst von: | Schaier, Matthias [VerfasserIn]  |
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| | Seissler, Nicole [VerfasserIn] |
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| | Becker, Luis Eduardo [VerfasserIn] |
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| | Schäfer, Sebastian Markus [VerfasserIn] |
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| | Schmitt, Edgar [VerfasserIn] |
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| | Meuer, Stefan [VerfasserIn] |
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| | Hug, Friederike [VerfasserIn] |
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| | Sommerer, Claudia [VerfasserIn] |
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| | Waldherr, Rüdiger [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Steinborn-Kröhl, Andrea [VerfasserIn] |
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| Titel: | The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection |
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| Verf.angabe: | Matthias Schaier, Nicole Seissler, Luis Eduardo Becker, Sebastian Markus Schaefer, Edgar Schmitt, Stefan Meuer, Friederike Hug, Claudia Sommerer, Rüdiger Waldherr, Martin Zeier and Andrea Steinborn |
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| E-Jahr: | 2013 |
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| Jahr: | 2 January 2013 |
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| Umfang: | 10 S. |
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| Fussnoten: | Im Text ist "+" hochgestellt ; Gesehen am 03.02.2022 |
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| Titel Quelle: | Enthalten in: Transplant international |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1988 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 26(2013), 3 vom: März, Seite 290-299 |
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| ISSN Quelle: | 1432-2277 |
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| Abstract: | Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR+-Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent of HLA-DR expression of HLA-DR+-Tregs (MFI HLA-DR) were estimated in non transplanted volunteers, patients with end-stage renal failure (ESRF), healthy renal transplant patients with suspicion on rejection, due to sole histological Bord-R or sole acute renal failure (ARF), and patients with clinically relevant borderline rejection (Bord-R and ARF). Compared to patients with only Bord-R or only ARF, the suppressive activity of the total Treg cell pool was exclusively reduced in patients with clinically relevant Bord-R. In parallel, the HLA-DR MFI of the DR+-Treg subset was significantly decreased in these patients, due to a significantly lower proportion of DRhigh+-Tregs, which were shown to have the highest suppressive capacity within the total Treg pool. Our findings clearly demonstrate that the determination of the HLA-DR MFI of the HLA-DR+-Treg subset allows a highly sensitive, specific and non-invasive discrimination between patients with clinically relevant Bord-R (Bord and ARF) and patients with subclinical rejection or other causes of transplant failure. |
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| DOI: | doi:10.1111/tri.12032 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/tri.12032 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.12032 |
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| | DOI: https://doi.org/10.1111/tri.12032 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | borderline rejection |
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| | non-invasive marker |
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| | renal transplantation |
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| | Tregs |
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| K10plus-PPN: | 1788447387 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection / Schaier, Matthias [VerfasserIn]; 2 January 2013 (Online-Ressource)
