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| Verfasst von: | Flommersfeld, Sophie [VerfasserIn]  |
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| | Böttcher, Jan P. [VerfasserIn] |
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| | Ersching, Jonatan [VerfasserIn] |
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| | Flossdorf, Michael [VerfasserIn] |
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| | Meiser, Philippa [VerfasserIn] |
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| | Pachmayr, Ludwig O. [VerfasserIn] |
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| | Leube, Justin [VerfasserIn] |
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| | Hensel, Inge [VerfasserIn] |
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| | Jarosch, Sebastian [VerfasserIn] |
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| | Zhang, Qin [VerfasserIn] |
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| | Chaudhry, M. Zeeshan [VerfasserIn] |
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| | Andrae, Immanuel [VerfasserIn] |
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| | Schiemann, Matthias [VerfasserIn] |
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| | Busch, Dirk. H. [VerfasserIn] |
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| | Cicin-Sain, Luka [VerfasserIn] |
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| | Sun, Joseph C. [VerfasserIn] |
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| | Gasteiger, Georg [VerfasserIn] |
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| | Victora, Gabriel D. [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| | Buchholz, Veit [VerfasserIn] |
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| | Grassmann, Simon [VerfasserIn] |
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| Titel: | Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection |
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| Verf.angabe: | Sophie Flommersfeld, Jan P. Böttcher, Jonatan Ersching, Michael Flossdorf, Philippa Meiser, Ludwig O. Pachmayr, Justin Leube, Inge Hensel, Sebastian Jarosch, Qin Zhang, M. Zeeshan Chaudhry, Immanuel Andrae, Matthias Schiemann, Dirk. H. Busch, Luka Cicin-Sain, Joseph C. Sun, Georg Gasteiger, Gabriel D. Victora, Thomas Höfer, Veit R. Buchholz, and Simon Grassmann |
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| E-Jahr: | 2021 |
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| Jahr: | 25 August 2021 |
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| Umfang: | 24 S. |
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| Fussnoten: | Gesehen am 03.02.2022 |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 54(2021,10), Seite 2288-2304, e1-e7, 24 Seiten |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s. |
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| DOI: | doi:10.1016/j.immuni.2021.08.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.immuni.2021.08.002 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1074761321003320 |
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| | DOI: https://doi.org/10.1016/j.immuni.2021.08.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adaptive-like NK cell responses |
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| | ILC1 |
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| | ILC1-like NK cells |
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| | MCMV |
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| | NK cells |
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| | single-cell fate mapping |
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| K10plus-PPN: | 1788456777 |
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| Verknüpfungen: | → Zeitschrift |
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Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection / Flommersfeld, Sophie [VerfasserIn]; 25 August 2021 (Online-Ressource)
