Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kaipa, Jagan Mohan [VerfasserIn]   i
 Starkuviene-Erfle, Vytaute [VerfasserIn]   i
 Erfle, Holger [VerfasserIn]   i
 Eils, Roland [VerfasserIn]   i
 Gladilin, Evgeny [VerfasserIn]   i
Titel:Transcriptome profiling reveals Silibinin dose-dependent response network in non-small lung cancer cells
Verf.angabe:Jagan Mohan Kaipa, Vytaute Starkuviene, Holger Erfle, Roland Eils, Evgeny Gladilin
E-Jahr:2020
Jahr:16 December 2020
Umfang:26 S.
Fussnoten:Gesehen am 04.02.2022
Titel Quelle:Enthalten in: PeerJ
Ort Quelle:London [u.a.] : PeerJ, Inc., 2013
Jahr Quelle:2020
Band/Heft Quelle:8(2020), 12, Artikel-ID e10373, Seite 1-26
ISSN Quelle:2167-8359
Abstract:Silibinin (SIL), a natural flavonolignan from the milk thistle (Silybum marianum), is known to exhibit remarkable hepatoprotective, antineoplastic and EMT inhibiting effects in different cancer cells by targeting multiple molecular targets and pathways. However, the predominant majority of previous studies investigated effects of this phytocompound in a one particular cell line. Here, we carry out a systematic analysis of dose-dependent viability response to SIL in five non-small cell lung cancer (NSCLC) lines that gradually differ with respect to their intrinsic EMT stage. By correlating gene expression profiles of NSCLC cell lines with the pattern of their SIL IC50 response, a group of cell cycle, survival and stress responsive genes, including some prominent targets of STAT3 (BIRC5, FOXM1, BRCA1), was identified. The relevancy of these computationally selected genes to SIL viability response of NSCLC cells was confirmed by the transient knockdown test. In contrast to other EMT-inhibiting compounds, no correlation between the SIL IC50 and the intrinsic EMT stage of NSCLC cells was observed. Our experimental results show that SIL viability response of differently constituted NSCLC cells is linked to a subnetwork of tightly interconnected genes whose transcriptomic pattern can be used as a benchmark for assessment of individual SIL sensitivity instead of the conventional EMT signature. Insights gained in this study pave the way for optimization of customized adjuvant therapy of malignancies using Silibinin.
DOI:doi:10.7717/peerj.10373
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.7717/peerj.10373
 Volltext: https://peerj.com/articles/10373
 DOI: https://doi.org/10.7717/peerj.10373
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1788517865
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68874223   QR-Code
zum Seitenanfang