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| Verfasst von: | Toberer, Ferdinand [VerfasserIn]  |
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| | Sykora, Jaromir [VerfasserIn] |
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| | Göttel, Daniel [VerfasserIn] |
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| | Hartschuh, Wolfgang [VerfasserIn] |
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| | Werchau, Siegfried Arthur [VerfasserIn] |
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| | Enk, Alexander [VerfasserIn] |
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| | Joos, Stefan [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Kuhn, Annegret [VerfasserIn] |
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| Titel: | Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus |
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| Titelzusatz: | analysis using tissue microarray |
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| Verf.angabe: | Ferdinand Toberer, Jaromir Sykora, Daniel Göttel, Wolfgang Hartschuh, Siegfried Werchau, Alexander Enk, Stefan Joos, Peter H. Krammer and Annegret Kuhn |
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| E-Jahr: | 2013 |
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| Jahr: | 08 August 2013 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 07.02.2022 |
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| Titel Quelle: | Enthalten in: Experimental dermatology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1992 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 22(2013), 10, Seite 656-659 |
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| ISSN Quelle: | 1600-0625 |
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| Abstract: | Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease. Different pathogenetic mechanisms, including the accumulation of apoptotic keratinocytes in CLE, have been reported. Therefore, we investigated whether CLE and other inflammatory skin diseases differ with regard to the epidermal expression of molecules that are crucial for the initiation and regulation of apoptosis. In this study, 241 skin biopsies from patients with CLE, psoriasis (PSO), lichen planus (LP) and healthy controls (HCs) were analysed immunohistochemically using the tissue microarray (TMA) technique. The TUNEL assay and anti-activated caspase-3 antibodies revealed a significant increase of apoptotic keratinocytes in CLE lesions compared with HCs. Furthermore, we detected a significant increase in the epidermal expression of CD95 in CLE specimens compared with PSO, LP and HCs. These data suggest that the accumulation of apoptotic keratinocytes in CLE might be due to the increased epidermal expression of CD95, resulting in increased activity of the extrinsic apoptotic pathway in the disease. |
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| DOI: | doi:10.1111/exd.12216 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/exd.12216 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.12216 |
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| | DOI: https://doi.org/10.1111/exd.12216 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | CD95 |
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| | cutaneous lupus erythematosus |
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| | tissue microarray |
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| K10plus-PPN: | 1788654870 |
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| Verknüpfungen: | → Zeitschrift |
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Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus / Toberer, Ferdinand [VerfasserIn]; 08 August 2013 (Online-Ressource)
