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| Verfasst von: | Schaich, Markus [VerfasserIn]  |
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| | Parmentier, Stefani [VerfasserIn] |
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| | Kramer, Michael [VerfasserIn] |
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| | Illmer, Thomas [VerfasserIn] |
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| | Stölzel, Friedrich [VerfasserIn] |
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| | Röllig, Christoph [VerfasserIn] |
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| | Thiede, Christian [VerfasserIn] |
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| | Hänel, Mathias [VerfasserIn] |
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| | Schäfer-Eckart, Kerstin [VerfasserIn] |
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| | Aulitzky, Walter [VerfasserIn] |
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| | Einsele, Hermann [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Serve, Hubert [VerfasserIn] |
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| | Berdel, Wolfgang E. [VerfasserIn] |
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| | Mayer, Jiri [VerfasserIn] |
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| | Schmitz, Norbert [VerfasserIn] |
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| | Krause, Stefan W. [VerfasserIn] |
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| | Neubauer, Andreas [VerfasserIn] |
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| | Baldus, Claudia D. [VerfasserIn] |
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| | Schetelig, Johannes [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Ehninger, Gerhard [VerfasserIn] |
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| Titel: | High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia |
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| Titelzusatz: | results of the prospective randomized AML2003 trial |
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| Verf.angabe: | Markus Schaich, Stefani Parmentier, Michael Kramer, Thomas Illmer, Friedrich Stölzel, Christoph Röllig, Christian Thiede, Mathias Hänel, Kerstin Schäfer-Eckart, Walter Aulitzky, Hermann Einsele, Anthony D. Ho, Hubert Serve, Wolfgang E. Berdel, Jiri Mayer, Norbert Schmitz, Stefan W. Krause, Andreas Neubauer, Claudia D. Baldus, Johannes Schetelig, Martin Bornhäuser, and Gerhard Ehninger |
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| Jahr: | 2013 |
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| Umfang: | 9 S. |
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| Fussnoten: | PDF Datei enthält noch 2 Seiten Anhang ; Gesehen am 08.02.2022 |
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| Titel Quelle: | Enthalten in: Journal of clinical oncology |
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| Ort Quelle: | Alexandria, Va. : American Society of Clinical Oncology, 1983 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 31(2013), 17, Seite 2094-2102 |
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| ISSN Quelle: | 1527-7755 |
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| Abstract: | Purpose - To assess the treatment outcome benefit of multiagent consolidation in young adults with acute myeloid leukemia (AML) in a prospective, randomized, multicenter trial. - Patients and Methods - Between December 2003 and November 2009, 1,179 patients (median age, 48 years; range, 16 to 60 years) with untreated AML were randomly assigned at diagnosis to receive either standard high-dose cytarabine consolidation with three cycles of 18 g/m2 (3× HD-AraC) or multiagent consolidation with two cycles of mitoxantrone (30 mg/m2) plus cytarabine (12 g/m2) and one cycle of amsacrine (500 mg/m2) plus cytarabine (10 g/m2; MAC/MAMAC/MAC). Allogeneic and autologous hematopoietic stem-cell transplantations were performed in a risk-adapted and priority-based manner. Results - After double induction therapy using a 3 + 7 regimen including standard-dose cytarabine and daunorubicin, complete remission was achieved in 65% of patients. In the primary efficacy population of patients evaluable for consolidation outcomes, consolidation with either 3× HD-AraC or MAC/MAMC/MAC did not result in any significant difference in 3-year overall (69% v 64%; P = .18) or disease-free survival (46% v 48%; P = .99) according to the intention-to-treat analysis. Furthermore, MAC/MAMAC/MAC led to additional GI and hepatic toxicity and a higher rate of infection and bleeding, resulting in significantly shorter 3-year overall survival in the per-protocol analysis compared with 3× HD-AraC (63% v 72%; P = .04). - Conclusion - In younger adults with AML, multiagent consolidation using mitoxantrone and amsacrine in combination with high-dose cytarabine does not improve treatment outcome and confers additional toxicity. |
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| DOI: | doi:10.1200/JCO.2012.46.4743 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1200/JCO.2012.46.4743 |
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| | Volltext: https://ascopubs.org/doi/10.1200/JCO.2012.46.4743 |
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| | DOI: https://doi.org/10.1200/JCO.2012.46.4743 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1788803027 |
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| Verknüpfungen: | → Zeitschrift |
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High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia / Schaich, Markus [VerfasserIn]; 2013 (Online-Ressource)
