| |  Online-Ressource |
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| Verfasst von: | Bronk, Lawrence [VerfasserIn]  |
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| | Guan, Fada [VerfasserIn] |
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| | Patel, Darshana [VerfasserIn] |
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| | Ma, Duo [VerfasserIn] |
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| | Kroger, Benjamin [VerfasserIn] |
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| | Wang, Xiaochun [VerfasserIn] |
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| | Tran, Kevin [VerfasserIn] |
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| | Yiu, Joycelyn [VerfasserIn] |
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| | Stephan, Clifford [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Abdollahi, Amir [VerfasserIn] |
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| | Jäkel, Oliver [VerfasserIn] |
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| | Mohan, Radhe [VerfasserIn] |
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| | Titt, Uwe [VerfasserIn] |
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| | Grosshans, David R. [VerfasserIn] |
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| Titel: | Mapping the relative biological effectiveness of proton, helium and carbon ions with high-throughput techniques |
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| Verf.angabe: | Lawrence Bronk, Fada Guan, Darshana Patel, Duo Ma, Benjamin Kroger, Xiaochun Wang, Kevin Tran, Joycelyn Yiu, Clifford Stephan, Jürgen Debus, Amir Abdollahi, Oliver Jäkel, Radhe Mohan, Uwe Titt and David R. Grosshans |
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| E-Jahr: | 2020 |
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| Jahr: | 5 December 2020 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 11.02.2020 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 12(2020), 12, Artikel-ID 3658, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Large amounts of high quality biophysical data are needed to improve current biological effects models but such data are lacking and difficult to obtain. The present study aimed to more efficiently measure the spatial distribution of relative biological effectiveness (RBE) of charged particle beams using a novel high-accuracy and high-throughput experimental platform. Clonogenic survival was selected as the biological endpoint for two lung cancer cell lines, H460 and H1437, irradiated with protons, carbon, and helium ions. Ion-specific multi-step microplate holders were fabricated such that each column of a 96-well microplate is spatially situated at a different location along a particle beam path. Dose, dose-averaged linear energy transfer (LETd), and dose-mean lineal energy (yd) were calculated using an experimentally validated Geant4-based Monte Carlo system. Cells were irradiated at the Heidelberg Ion Beam Therapy Center (HIT). The experimental results showed that the clonogenic survival curves of all tested ions were yd-dependent. Both helium and carbon ions achieved maximum RBEs within specific yd ranges before biological efficacy declined, indicating an overkill effect. For protons, no overkill was observed, but RBE increased distal to the Bragg peak. Measured RBE profiles strongly depend on the physical characteristics such as yd and are ion specific. |
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| DOI: | doi:10.3390/cancers12123658 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers12123658 |
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| | Volltext: https://www.mdpi.com/2072-6694/12/12/3658 |
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| | DOI: https://doi.org/10.3390/cancers12123658 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | charged particle therapy |
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| | high-throughput techniques |
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| | lung cancer cells |
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| | relative biological effectiveness |
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| K10plus-PPN: | 178888311X |
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| Verknüpfungen: | → Zeitschrift |
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Mapping the relative biological effectiveness of proton, helium and carbon ions with high-throughput techniques / Bronk, Lawrence [VerfasserIn]; 5 December 2020 (Online-Ressource)
