Quantification of tissue shrinkage and dehydration caused by microwave ablation

• Verfasst von: Sommer, Christof-Matthias [VerfasserIn]
• Verfasst von: Sommer, Steffen A. [VerfasserIn]
• Verfasst von: Mokry, Theresa [VerfasserIn]
• Verfasst von: Gockner, Theresa [VerfasserIn]
• Verfasst von: Gnutzmann, Daniel [VerfasserIn]
• Verfasst von: Bellemann, Nadine [VerfasserIn]
• Verfasst von: Schmitz, Anne [VerfasserIn]
• Verfasst von: Radeleff, Boris [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Stampfl, Ulrike [VerfasserIn]
• Verfasst von: Pereira, Philippe L. [VerfasserIn]
• Titel: Quantification of tissue shrinkage and dehydration caused by microwave ablation
• Titelzusatz: experimental study in kidneys for the estimation of effective coagulation volume
• Verf.angabe: Christof M. Sommer, Steffen A. Sommer, Theresa Mokry, Theresa Gockner, Daniel Gnutzmann, Nadine Bellemann, Anne Schmitz, Boris A. Radeleff, Hans U. Kauczor, Ulrike Stampfl, and Philippe L. Pereira
• Jahr: 2013
• Umfang: 8 S.
• Fussnoten: Available online 20 June 2013 ; Gesehen am 09.02.2022
• Titel Quelle: Enthalten in: Journal of vascular and interventional radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1990
• Jahr Quelle: 2013
• Band/Heft Quelle: 24(2013), 8 vom: Aug., Seite 1241-1248
• ISSN Quelle: 1535-7732
• DOI: doi:10.1016/j.jvir.2013.04.008
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 178910436X

Abstract

Purpose - To quantify the extent of tissue shrinkage and dehydration caused by microwave (MW) ablation in kidneys for estimation of effective coagulation volume. - Materials and Methods - MW ablations were carried out in ex vivo porcine kidneys. Six study groups were defined: groups 1A, 2A, and 3A for MW ablation (90 W for 5 min, 7.5 min, or 10 min), and groups 1B, 2B, and 3B for control (without MW ablation). Pre- and postinterventional volume analyses were performed. Effective coagulation volumes (original tissue included in coagulation) were determined. Postinterventional dehydration analyses were performed with calculation of mean mass fractions of water. - Results - Mean deployed energies were 21.6 kJ ± 1.1 for group 1A, 29.9 kJ ± 1.0 for group 2A, and 42.1 kJ ± 0.5 kJ for group 3A, and were significantly different (P < .0001). Differences between pre- and postinterventional volumes were −3.8% ± 0.6 for group 1A, −5.6% ± 0.9 for group 2A, and −7.2% ± 0.4 for group 3A, and −1.1% ± 0.3 for group 1B, −1.8% ± 0.4 for group 2B, and −1.1% ± 0.4 for group 3B. Postinterventional volumes were significantly smaller than preinterventional volumes for all groups (P < .01). Underestimations of effective coagulation volume from visualized coagulation volume were 26.1% ± 3.5 for group 1A, 35.2% ± 11.2 for group 2A, and 42.1% ± 4.9 for group 3A, which were significantly different (P < .01). Mean mass fractions of water were 64.2% ± 1.4 for group 1A, 63.2% ± 1.7 for group 2A, and 62.6% ± 1.8% for group 3A, with significant differences versus corresponding control groups (P < .01). - Conclusions - For MW ablation in kidneys, underestimation of effective coagulation volume based on visualized coagulation volume is significantly greater with greater deployed energy. Therefore, local dehydration with tissue shrinkage is a potential contributor.