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Verfasst von:Tomaschitz, Andreas [VerfasserIn]   i
 Pilz, Stefan [VerfasserIn]   i
 Pieske, Burkert [VerfasserIn]   i
 Ritz, Eberhard [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
 Meinitzer, Andreas [VerfasserIn]   i
 Dobnig, Harald [VerfasserIn]   i
 Amrein, Karin [VerfasserIn]   i
 Kienreich, Katharina [VerfasserIn]   i
 Verheyen, Nicolas [VerfasserIn]   i
 Kraigher-Krainer, Elisabeth [VerfasserIn]   i
 Drechsler, Christiane [VerfasserIn]   i
 Colantonio, Caterina [VerfasserIn]   i
 Wagner, Doris [VerfasserIn]   i
 Fahrleitner-Pammer, Astrid [VerfasserIn]   i
Titel:Circulating aldosterone and mortality in female nursing home residents
Verf.angabe:Andreas Tomaschitz, Stefan Pilz, Burkert Pieske, Eberhard Ritz, Winfried März, Andreas Meinitzer, Harald Dobnig, Karin Amrein, Katharina Kienreich, Nicolas Verheyen, Elisabeth Kraigher-Krainer, Christiane Drechsler, Caterina Colantonio, Doris Wagner, Astrid Fahrleitner-Pammer
E-Jahr:2013
Jahr:16 January 2013
Umfang:6 S.
Fussnoten:Gesehen am 10.02.2022
Titel Quelle:Enthalten in: Experimental gerontology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1964
Jahr Quelle:2013
Band/Heft Quelle:48(2013), 3, Seite 313-318
ISSN Quelle:1873-6815
Abstract:Objectives - To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. - Methods - Individuals aged 70years and older were recruited from 95 nursing homes in Austria. Participants were enrolled and followed up by mobile study teams. All participants underwent an extensive health examination and were followed until death or end of the study. Serum aldosterone concentration (SAC) was measured at baseline after exclusion of twenty seven patients taking mineralocorticoid-receptor (MR) blockers. - Results - Median SAC was 171.1 (IQR: 103.2-303.4) pg/mL (normal range: 30-400) in 471 female individuals (mean age: 83.7±6.2years). After a median follow-up of 27±8months, a total of 121 (25.7%) participants died. In multivariable Cox proportional hazard analysis, SAC levels stratified in quartiles were significantly associated with all-cause mortality. Compared with the reference (first) SAC quartile, the Cox proportional hazard ratio (confidence interval 95%) for the fourth SAC quartiles was 1.94, 95% CI=1.08-3.46, p=0.026. We found statistically significant interaction terms between SAC-related mortality and the presence of advanced heart failure (NYHA functional class III; p=0.038), HbA1c (p=0.043) and eGFR levels (p=0.030). - Conclusions - Higher circulating aldosterone levels are related to an increased mortality risk in elderly female nursing home residents. Interventional studies are needed to assess the potential influence of MR blockade on “hard” clinical outcomes in individuals aged 70years and older.
DOI:doi:10.1016/j.exger.2013.01.004
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.exger.2013.01.004
 Volltext: https://www.sciencedirect.com/science/article/pii/S0531556513000107
 DOI: https://doi.org/10.1016/j.exger.2013.01.004
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Circulating aldosterone and mortality in female nursing home residents. - 2013
Sach-SW:Aldosterone
 Elderly female individuals
 Heart failure
 Mortality
 Nursing home residents
K10plus-PPN:1789189144
Verknüpfungen:→ Zeitschrift

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