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| Verfasst von: | Tran, Thuong Hien [VerfasserIn]  |
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| | Unterrainer, Christian [VerfasserIn] |
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| | Fiedler, Gerd [VerfasserIn] |
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| | Döhler, Bernd [VerfasserIn] |
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| | Scherer, Sabine [VerfasserIn] |
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| | Ruhenstroth, Andrea [VerfasserIn] |
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| | Adamek, Martina Maria [VerfasserIn] |
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| | Middleton, D. [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| Titel: | No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation |
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| Verf.angabe: | T.H. Tran, C. Unterrainer, G. Fiedler, B. Döhler, S. Scherer, A. Ruhenstroth, M. Adamek, D. Middleton and G. Opelz |
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| E-Jahr: | 2013 |
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| Jahr: | 07 February 2013 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 10.02.2022 |
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| Titel Quelle: | Enthalten in: American journal of transplantation |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 2001 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 13(2013), 4, Seite 1063-1068 |
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| ISSN Quelle: | 1600-6143 |
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| Abstract: | Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been shown by van Bergen et al. (American Journal of Transplantation 2011; 11(9): 1959-1964) to be a significant risk factor for long-term graft loss in HLA-A, -B and -DR compatible kidney transplants. To verify this potentially important finding, we performed genotyping of 608 deceased-donor kidney graft recipients and their HLA-A, -B and -DR compatible donors for KIR and HLA, using samples and clinical data provided by the Collaborative Transplant Study. Graft survival of KIR-ligand-matched and -mismatched transplants was compared. We found no impact of KIR-ligand mismatching on 10-year graft survival in HLA-A, -B, -DR compatible kidney transplants. Further analysis did not reveal a significant effect of recipient activating/inhibitory KIR or KIR genotypes on graft survival. Our data do not support the concept that KIR-HLA matching might serve as a tool to improve long-term renal allograft survival. |
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| DOI: | doi:10.1111/ajt.12134 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/ajt.12134 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.12134 |
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| | DOI: https://doi.org/10.1111/ajt.12134 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Graft survival |
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| | HLA |
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| | kidney transplantation |
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| | KIR |
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| K10plus-PPN: | 1789200385 |
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| Verknüpfungen: | → Zeitschrift |
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No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation / Tran, Thuong Hien [VerfasserIn]; 07 February 2013 (Online-Ressource)
