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| Verfasst von: | Cremer, Friedrich Walter [VerfasserIn]  |
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| | Bila, Jelena [VerfasserIn] |
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| | Buck, Isabelle [VerfasserIn] |
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| | Kartal-Kaess, Mutlu [VerfasserIn] |
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| | Hose, Dirk [VerfasserIn] |
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| | Ittrich, Carina [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Theil, Ann-Cathrin [VerfasserIn] |
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| | Moos, Marion [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Bartram, Claus R. [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| Titel: | Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics |
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| Verf.angabe: | Friedrich W. Cremer, Jelena Bila, Isabelle Buck, Mutlu Kartal, Dirk Hose, Carina Ittrich, Axel Benner, Marc S. Raab, Ann-Cathrin Theil, Marion Moos, Hartmut Goldschmidt, Claus R. Bartram, Anna Jauch |
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| E-Jahr: | 2005 |
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| Jahr: | 06 July 2005 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 15.02.2022 |
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| Titel Quelle: | Enthalten in: Genes, chromosomes & cancer |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1989 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 44(2005), 2, Seite 194-203 |
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| ISSN Quelle: | 1098-2264 |
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| Abstract: | To delineate multiple myeloma (MM) subgroups and their clonal evolution, we analyzed 81 newly diagnosed patients by interphase fluorescence in situ hybridization using a comprehensive probe set for 10 chromosomes and two IGH rearrangements. A median of 5 probes per patient displayed aberrant signal numbers (range, 1-10). Additional copies most frequently found were for 15q22, 19q13, 9q34, 11q23, and 1q21. Losses commonly observed were of 13q14.3, 17p13, and 22q11. Predominance of gain or loss was quantified by a copy number score (CS) for each patient. Two peaks (CS = +3 and CS = 0) were found by plotting patient copy number scores over CS values corresponding to hyperdiploid and nonhyperdiploid MM. Cluster analysis revealed four major branches: (i) gain of 9q, 15q, 19q, and/or 11q; (ii) deletion of 13q and t(4;14); (iii) t(11;14); and (iv) gain of 1q. Statistical modeling of an oncogenetic tree indicated that early independent events were gain of 15q/9q and/or 11q, t(11;14); deletion of 13q followed by t(4;14); and gain of 1q. Aberrations of 17p13, 22q11, 8p12, and 6q21 were found as subsequent events. MM with gain of 1q was delineated as a subentity with significantly higher beta-2-microglobulin and lower hemoglobin levels, indicating a poor prognosis. From our results, we propose a model of MM for clonal evolution. © 2005 Wiley-Liss, Inc. |
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| DOI: | doi:10.1002/gcc.20231 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/gcc.20231 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.20231 |
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| | DOI: https://doi.org/10.1002/gcc.20231 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1789632420 |
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| Verknüpfungen: | → Zeitschrift |
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Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics / Cremer, Friedrich Walter [VerfasserIn]; 06 July 2005 (Online-Ressource)
