Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Farr, Elias [VerfasserIn]  |
| Sattler, Julia M. [VerfasserIn]  |
| Frischknecht, Friedrich [VerfasserIn]  |
Titel: | SPOT |
Titelzusatz: | a web-tool enabling swift profiling of transcriptomes |
Verf.angabe: | Elias B. Farr, Julia M. Sattler, Friedrich Frischknecht |
E-Jahr: | 2022 |
Jahr: | 1 January 2022 |
Umfang: | 2 S. |
Fussnoten: | Gesehen am 18.02.2022 |
Titel Quelle: | Enthalten in: Bioinformatics |
Ort Quelle: | Oxford : Oxford Univ. Press, 1985 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 38(2022), 1, Seite 284-285 |
ISSN Quelle: | 1367-4811 |
Abstract: | The increasing number of single cell and bulk RNAseq datasets describing complex gene expression profiles in different organisms, organs or cell types calls for an intuitive tool allowing rapid comparative analysis. Here, we present Swift Profiling Of Transcriptomes (SPOT) as a web tool that allows not only differential expression analysis but also fast ranking of genes fitting transcription profiles of interest. Based on a heuristic approach the spot algorithm ranks the genes according to their proximity to the user-defined gene expression profile of interest. The best hits are visualized as a table, bar chart or dot plot and can be exported as an Excel file. While the tool is generally applicable, we tested it on RNAseq data from malaria parasites that undergo multiple stage transformations during their complex life cycle as well as on data from multiple human organs during development and cell lines infected by SARS-CoV-2. SPOT should enable non-bioinformaticians to easily analyse their own and any available dataset.SPOT is freely available for (academic) use at: https://frischknechtlab.shinyapps.io/SPOT/ and https://github.com/EliasFarr/SPOT.Supplementary data are available at Bioinformatics online. |
DOI: | doi:10.1093/bioinformatics/btab541 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1093/bioinformatics/btab541 |
| kostenfrei: Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406885 |
| DOI: https://doi.org/10.1093/bioinformatics/btab541 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1790163250 |
Verknüpfungen: | → Zeitschrift |
SPOT / Farr, Elias [VerfasserIn]; 1 January 2022 (Online-Ressource)
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