| |  Online-Ressource |
|---|
| Verfasst von: | Hopp, Ann-Katrin [VerfasserIn]  |
|---|
| | Teloni, Federico [VerfasserIn] |
|---|
| | Bisceglie, Lavinia [VerfasserIn] |
|---|
| | Gondrand, Corentin [VerfasserIn] |
|---|
| | Raith, Fabio [VerfasserIn] |
|---|
| | Nowak, Kathrin [VerfasserIn] |
|---|
| | Muskalla, Lukas [VerfasserIn] |
|---|
| | Howald, Anna [VerfasserIn] |
|---|
| | Pedrioli, Patrick G. A. [VerfasserIn] |
|---|
| | Johnsson, Kai [VerfasserIn] |
|---|
| | Altmeyer, Matthias O. [VerfasserIn] |
|---|
| | Pedrioli, Deena M. Leslie [VerfasserIn] |
|---|
| | Hottiger, Michael [VerfasserIn] |
|---|
| Titel: | Mitochondrial NAD+ controls nuclear ARTD1-induced ADP-ribosylation |
|---|
| Verf.angabe: | Ann-Katrin Hopp, Federico Teloni, Lavinia Bisceglie, Corentin Gondrand, Fabio Raith, Kathrin Nowak, Lukas Muskalla, Anna Howald, Patrick G.A. Pedrioli, Kai Johnsson, Matthias Altmeyer, Deena M. Leslie Pedrioli, Michael O. Hottiger |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 14 January 2021 |
|---|
| Umfang: | 21 S. |
|---|
| Fussnoten: | Gesehen am 09.09.2021 ; Im Titel ist "+" hochgestellt |
|---|
| Titel Quelle: | Enthalten in: Molecular cell |
|---|
| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1997 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 81(2021), 2, Seite 340-354,e1-e5 |
|---|
| ISSN Quelle: | 1097-4164 |
|---|
| Abstract: | In addition to its role as an electron transporter, mitochondrial nicotinamide adenine dinucleotide (NAD(+)) is an important co-factor for enzymatic reactions, including ADP-ribosylation. Although mitochondria harbor the most intra-cellular NAD(+), mitochondrial ADP-ribosylation remains poorly understood. Here we provide evidence for mitochondrial ADP-ribosylation, which was identified using various methodologies including immunofluorescence, western blot, and mass spectrometry. We show that mitochondrial ADP-ribosylation reversibly increases in response to respiratory chain inhibition. Conversely, H2O2-induced oxidative stress reciprocally induces nuclear and reduces mitochondrial ADP-ribosylation. Elevated mitochondrial ADP-ribosylation, in turn, dampens H2O2-triggered nuclear ADP-ribosylation and increases MMS-induced ARTD1 chromatin retention. Interestingly, co-treatment of cells with the mitochondrial uncoupler FCCP decreases PARP inhibitor efficacy. Together, our results suggest that mitochondrial ADP-ribosylation is a dynamic cellular process that impacts nuclear ADP-ribosylation and provide evidence for a NAD(+)-mediated mitochondrial-nuclear crosstalk. |
|---|
| DOI: | doi:10.1016/j.molcel.2020.12.034 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.molcel.2020.12.034 |
|---|
| | Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2 ... |
|---|
| | DOI: https://doi.org/10.1016/j.molcel.2020.12.034 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | astrocytes |
|---|
| | binding |
|---|
| | cell-death |
|---|
| | depletion |
|---|
| | dinucleotide |
|---|
| | dynamics |
|---|
| | nicotinamide |
|---|
| | poly(adp-ribose) polymerase |
|---|
| | reveals |
|---|
| | roles |
|---|
| K10plus-PPN: | 1769927107 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Mitochondrial NAD+ controls nuclear ARTD1-induced ADP-ribosylation / Hopp, Ann-Katrin [VerfasserIn]; 14 January 2021 (Online-Ressource)
