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Status: Bibliographieeintrag

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Verfasst von:Yamada, Yosuke [VerfasserIn]   i
 Simon-Keller, Katja [VerfasserIn]   i
 Belharazem, Djeda [VerfasserIn]   i
 Bohnenberger, Hanibal [VerfasserIn]   i
 Kriegsmann, Mark [VerfasserIn]   i
 Kriegsmann, Katharina [VerfasserIn]   i
 Hamilton, Gerhard [VerfasserIn]   i
 Graeter, Thomas [VerfasserIn]   i
 Preissler, Gerhard [VerfasserIn]   i
 Ott, German [VerfasserIn]   i
 Roessner, Eric Dominic [VerfasserIn]   i
 Dahmen, Ilona [VerfasserIn]   i
 Thomas, Roman K. [VerfasserIn]   i
 Ströbel, Philipp [VerfasserIn]   i
 Marx, Alexander [VerfasserIn]   i
Titel:A tuft cell-like signature is highly prevalent in thymic squamous cell carcinoma and delineates new molecular subsets among the major lung cancer histotypes
Verf.angabe:Yosuke Yamada, MD, PhD, Katja Simon-Keller, PhD, Djeda Belharazem-Vitacolonnna, PhD, Hanibal Bohnenberger, MD, Mark Kriegsmann, MD, Katharina Kriegsmann, MD, Gerhard Hamilton, MD, Thomas Graeter, MD, Gerhard Preissler, MD, German Ott, MD, Eric Dominic Roessner, MD, Ilona Dahmen, Roman K. Thomas, MD, Philipp Ströbel, MD, Alexander Marx, MD
E-Jahr:2021
Jahr:17 February 2021
Umfang:14 S.
Fussnoten:Gesehen am 22.02.2022
Titel Quelle:Enthalten in: Journal of thoracic oncology
Ort Quelle:Amsterdam : Elsevier, 2006
Jahr Quelle:2021
Band/Heft Quelle:16(2021), 6 vom: Juni, Seite 1003-1016
ISSN Quelle:1556-1380
Abstract:Introduction - In-depth genomic characterization of thymic epithelial tumors (TETs), comprising thymomas and thymic carcinomas (TCs), failed to identify targetable mutations and suggested unique biology of TETs, including KIT expression in most TCs. Recently, tuft cell-like medullary thymic epithelial cells were identified in the murine thymus, and our reanalysis of the published gene expression data revealed that these cells express KIT. In addition, recently, a minor subset of SCLCs with tuft cell-like features was described. - Methods - We interrogated mRNA expression data from our tumor cohorts (N = 60) and publicly available, independent data sets from TETs and NSCLC (N = 1199) for expression of tuft cell genes and KIT. Expression of KIT and of POU2F3 protein, the master regulator of tuft cells, was analyzed in cancer tissue (N = 344) by immunohistochemistry. - Results - Normal human thymic tuft cells and most TCs coexpressed KIT and known tuft cell genes, particularly POU2F3 and GFI1B. Unexpectedly, small subsets of tuft cell-like tumors coexpressing POU2F3, GFI1B, and KIT were also identified among pulmonary squamous cell carcinomas, adenocarcinomas, and large cell neuroendocrine carcinoma and clustered together in each histologic cohort. In addition to the tuft cell-like signature, both thymic and lung tuft cell-like carcinomas had distinct genetic, pathologic, and clinical features in each cohort. - Conclusions - We suggest that the tuft cell-like phenotype defines novel subsets of thymic and pulmonary carcinoma. Its high prevalence in thymic squamous cell carcinomas that have no known toxic or viral etiologies suggests a new mechanism of carcinogenesis that may lead to specific drug susceptibilities.
DOI:doi:10.1016/j.jtho.2021.02.008
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jtho.2021.02.008
 Volltext: https://www.sciencedirect.com/science/article/pii/S1556086421017081
 DOI: https://doi.org/10.1016/j.jtho.2021.02.008
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:KIT
 Lung cancer
 POU2F3
 Thymic carcinoma
 Tuft cells
K10plus-PPN:1793488533
Verknüpfungen:→ Zeitschrift

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