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Verfasst von:Stolzenburg, Jens-Uwe [VerfasserIn]   i
 Holze, Sigrun [VerfasserIn]   i
 Neuhaus, Petra [VerfasserIn]   i
 Kyriazis, Iason [VerfasserIn]   i
 Do, Hoang Minh [VerfasserIn]   i
 Dietel, Anja [VerfasserIn]   i
 Truss, Michael C. [VerfasserIn]   i
 Grzella, Corinn I. [VerfasserIn]   i
 Teber, Dogu [VerfasserIn]   i
 Hohenfellner, Markus [VerfasserIn]   i
 Rabenalt, Robert [VerfasserIn]   i
 Albers, Peter [VerfasserIn]   i
 Mende, Meinhard [VerfasserIn]   i
Titel:Robotic-assisted versus laparoscopic surgery
Titelzusatz:outcomes from the first multicentre, randomised, patient-blinded controlled trial in radical prostatectomy (LAP-01)
Verf.angabe:Jens-Uwe Stolzenburg, Sigrun Holze, Petra Neuhaus, Iason Kyriazis, Hoang Minh Do, Anja Dietel, Michael C. Truss, Corinn I. Grzella, Dogu Teber, Markus Hohenfellner, Robert Rabenalt, Peter Albers, Meinhard Mende
Jahr:2021
Umfang:10 S.
Fussnoten:Gesehen am 23.02.2022
Titel Quelle:Enthalten in: European urology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1976
Jahr Quelle:2021
Band/Heft Quelle:79(2021), 6, Seite 750-759
ISSN Quelle:1873-7560
 1421-993X
Abstract:Background - The LAP-01 trial was designed to address the lack of high-quality literature comparing robotic-assisted (RARP) and laparoscopic (LRP) radical prostatectomy. - Objective - To compare the functional and oncological outcomes between RARP and LRP at 3 mo of follow-up. - Design, setting, and participants - In this multicentre, randomised, patient-blinded controlled trial, patients referred for radical prostatectomy to four hospitals in Germany were randomly assigned (3:1) to undergo either RARP or LRP. - Outcome measurements and statistical analysis - The primary outcome was time to continence recovery at 3 mo based on the patient’s pad diary. Secondary outcomes included continence and potency as well as quality of life in addition to oncological outcomes for up to 3 yr of follow-up. Time to continence was analysed by log-rank test and depicted by the Kaplan-Meier method. Continuous measurements were analysed by means of linear mixed models. - Results and limitations - A total of 782 patients were randomised. The primary endpoint was evaluable in 718 patients (547 RARPs; full analysis set). At 3 mo, the difference in continence rates was 8.7% in favour of RARP (54% vs 46%, p =  0.027). RARP remained superior to LRP even after adjustment for the randomisation stratum nerve sparing and age >65 yr (hazard ratio = 1.40 [1.09-1.81], p =  0.008). A significant benefit in early potency recovery was also identified, while similar oncological and morbidity outcomes were documented. It is a limitation that the influence of different anastomotic techniques was not investigated in this study. - Conclusions - RARP resulted in significantly better continence recovery at 3 mo. - Patient summary - In this randomised trial, we looked at the outcomes following radical prostate surgery in a large German population. We conclude that patients undergoing robotic prostatectomy had better continence than those undergoing laparoscopic surgery when assessed at 3 mo following surgery. Age and the nerve-sparing technique further affected continence restoration.
DOI:doi:10.1016/j.eururo.2021.01.030
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.eururo.2021.01.030
 Volltext: https://www.sciencedirect.com/science/article/pii/S0302283821000695
 DOI: https://doi.org/10.1016/j.eururo.2021.01.030
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Continence
 Laparoscopic prostatectomy
 Multicentre randomised trial
 Prostate cancer
 Prostatectomy
 Robotic-assisted prostatectomy
K10plus-PPN:1793750041
Verknüpfungen:→ Zeitschrift

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