| Online-Ressource |
Verfasst von: | Stolzenburg, Jens-Uwe [VerfasserIn]  |
| Holze, Sigrun [VerfasserIn]  |
| Neuhaus, Petra [VerfasserIn]  |
| Kyriazis, Iason [VerfasserIn]  |
| Do, Hoang Minh [VerfasserIn]  |
| Dietel, Anja [VerfasserIn]  |
| Truss, Michael C. [VerfasserIn]  |
| Grzella, Corinn I. [VerfasserIn]  |
| Teber, Dogu [VerfasserIn]  |
| Hohenfellner, Markus [VerfasserIn]  |
| Rabenalt, Robert [VerfasserIn]  |
| Albers, Peter [VerfasserIn]  |
| Mende, Meinhard [VerfasserIn]  |
Titel: | Robotic-assisted versus laparoscopic surgery |
Titelzusatz: | outcomes from the first multicentre, randomised, patient-blinded controlled trial in radical prostatectomy (LAP-01) |
Verf.angabe: | Jens-Uwe Stolzenburg, Sigrun Holze, Petra Neuhaus, Iason Kyriazis, Hoang Minh Do, Anja Dietel, Michael C. Truss, Corinn I. Grzella, Dogu Teber, Markus Hohenfellner, Robert Rabenalt, Peter Albers, Meinhard Mende |
Jahr: | 2021 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 23.02.2022 |
Titel Quelle: | Enthalten in: European urology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1976 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 79(2021), 6, Seite 750-759 |
ISSN Quelle: | 1873-7560 |
| 1421-993X |
Abstract: | Background - The LAP-01 trial was designed to address the lack of high-quality literature comparing robotic-assisted (RARP) and laparoscopic (LRP) radical prostatectomy. - Objective - To compare the functional and oncological outcomes between RARP and LRP at 3 mo of follow-up. - Design, setting, and participants - In this multicentre, randomised, patient-blinded controlled trial, patients referred for radical prostatectomy to four hospitals in Germany were randomly assigned (3:1) to undergo either RARP or LRP. - Outcome measurements and statistical analysis - The primary outcome was time to continence recovery at 3 mo based on the patient’s pad diary. Secondary outcomes included continence and potency as well as quality of life in addition to oncological outcomes for up to 3 yr of follow-up. Time to continence was analysed by log-rank test and depicted by the Kaplan-Meier method. Continuous measurements were analysed by means of linear mixed models. - Results and limitations - A total of 782 patients were randomised. The primary endpoint was evaluable in 718 patients (547 RARPs; full analysis set). At 3 mo, the difference in continence rates was 8.7% in favour of RARP (54% vs 46%, p = 0.027). RARP remained superior to LRP even after adjustment for the randomisation stratum nerve sparing and age >65 yr (hazard ratio = 1.40 [1.09-1.81], p = 0.008). A significant benefit in early potency recovery was also identified, while similar oncological and morbidity outcomes were documented. It is a limitation that the influence of different anastomotic techniques was not investigated in this study. - Conclusions - RARP resulted in significantly better continence recovery at 3 mo. - Patient summary - In this randomised trial, we looked at the outcomes following radical prostate surgery in a large German population. We conclude that patients undergoing robotic prostatectomy had better continence than those undergoing laparoscopic surgery when assessed at 3 mo following surgery. Age and the nerve-sparing technique further affected continence restoration. |
DOI: | doi:10.1016/j.eururo.2021.01.030 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.eururo.2021.01.030 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0302283821000695 |
| DOI: https://doi.org/10.1016/j.eururo.2021.01.030 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Continence |
| Laparoscopic prostatectomy |
| Multicentre randomised trial |
| Prostate cancer |
| Prostatectomy |
| Robotic-assisted prostatectomy |
K10plus-PPN: | 1793750041 |
Verknüpfungen: | → Zeitschrift |
Robotic-assisted versus laparoscopic surgery / Stolzenburg, Jens-Uwe [VerfasserIn]; 2021 (Online-Ressource)