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| Verfasst von: | Cremer, Friedrich Walter [VerfasserIn]  |
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| | Kartal-Kaess, Mutlu [VerfasserIn] |
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| | Hose, Dirk [VerfasserIn] |
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| | Bila, Jelena [VerfasserIn] |
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| | Buck, Isabelle [VerfasserIn] |
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| | Bellos, Frauke Liana [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Brough, Michaela [VerfasserIn] |
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| | Moebus, Anke [VerfasserIn] |
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| | Hager, Hans-Dieter [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Moos, Marion [VerfasserIn] |
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| | Bartram, Claus R. [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| Titel: | High incidence and intraclonal heterogeneity of chromosome 11 aberrations in patients with newly diagnosed multiple myeloma detected by multiprobe interphase FISH |
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| Verf.angabe: | Friedrich W. Cremer, Mutlu Kartal, Dirk Hose, Jelena Bila, Isabelle Buck, Frauke Bellos, Marc-Steffen Raab, Michaela Brough, Anke Moebus, Hans-Dieter Hager, Hartmut Goldschmidt, Marion Moos, Claus R. Bartram, Anna Jauch |
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| E-Jahr: | 2005 |
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| Jahr: | [September 2005] |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 25.02.2022 |
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| Titel Quelle: | Enthalten in: Cancer genetics and cytogenetics |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 161(2005), 2 vom: Sept., Seite 116-124 |
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| ISSN Quelle: | 1873-4456 |
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| Abstract: | In multiple myeloma, additional copies of chromosome 11 material, reported to confer an unfavorable prognosis, have been found in 20-45% of patients. To assess the incidence and extent of chromosome 11 aberrations, we performed interphase fluorescence in situ hybridization on CD138+ bone marrow plasma cells of 50 newly diagnosed myeloma patients, using seven locus-specific probes for chromosome 11, one for 13q14.3, and a probe set for translocation t(11;14). In 33 of 50 patients, chromosome 11 aberrations were found. Results indicated a marked intraclonal heterogeneity: in 13 patients, trisomy 11; in 10 patients, subclones with trisomy 11 and partial trisomies 11q coexisted; in 6 patients, only a partial trisomy 11q; and in 6 patients, a tetrasomy or partial tetrasomy 11. The coexistence of subclones with varying extent and copy numbers of chromosome 11 material indicates ongoing structural changes and clonal evolution. Hybridization results delineated 11q23 and 11q25 as the most frequently gained regions, which supports a relevant pathogenetic role of genes on 11q23 and 11q25. To confirm the high incidence of 11q23 gains, a further 50 patients (total n=100) were analyzed for 11q23 and 13q14.3. Myeloma with gains of 11q23 showed a low frequency of deletion 13q14.3 and may prove to be a distinct subgroup of this disease. |
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| DOI: | doi:10.1016/j.cancergencyto.2005.02.015 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cancergencyto.2005.02.015 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0165460805001160 |
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| | DOI: https://doi.org/10.1016/j.cancergencyto.2005.02.015 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1793889171 |
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| Verknüpfungen: | → Zeitschrift |
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High incidence and intraclonal heterogeneity of chromosome 11 aberrations in patients with newly diagnosed multiple myeloma detected by multiprobe interphase FISH / Cremer, Friedrich Walter [VerfasserIn]; [September 2005] (Online-Ressource)
