Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma

• Verfasst von: Nosàs-Garcia, Sílvia [VerfasserIn]
• Verfasst von: Möhler, Thomas [VerfasserIn]
• Verfasst von: Wasser, Klaus [VerfasserIn]
• Verfasst von: Kießling, Fabian [VerfasserIn]
• Verfasst von: Bartl, Reiner [VerfasserIn]
• Verfasst von: Zuna, Ivan [VerfasserIn]
• Verfasst von: Hillengaß, Jens [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Delorme, Stefan [VerfasserIn]
• Titel: Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma
• Titelzusatz: a comparative study with histology and clinical markers
• Verf.angabe: Sílvia Nosàs-Garcia, Thomas Moehler, Klaus Wasser, Fabian Kiessling, Reiner Bartl, Ivan Zuna, Jens Hillengass, Hartmut Goldschmidt, Hans-Ulrich Kauczor, and Stefan Delorme
• E-Jahr: 2005
• Jahr: 21 June 2005
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 25.02.2022
• Titel Quelle: Enthalten in: Journal of magnetic resonance imaging
• Ort Quelle: New York, NY : Wiley-Liss, 1991
• Jahr Quelle: 2005
• Band/Heft Quelle: 22(2005), 1 vom: Juni, Seite 154-162
• ISSN Quelle: 1522-2586
• DOI: doi:10.1002/jmri.20349
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: angiogenesis
• Sach-SW: dynamic MRI
• Sach-SW: infiltration
• Sach-SW: multiple myeloma
• Sach-SW: vessel density
• K10plus-PPN: 1793894132

Abstract

Purpose To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens. Materials and Methods The pelvis of 24 patients with multiple myeloma (MM) was examined using contrast-enhanced DCE MRI. Biopsy was obtained from the spina iliaca posterior superior. Using a two-compartment model (assuming one intravascular and one interstitial compartment), the parameters amplitude (A, the maximum, relative signal increase over baseline) and the exchange rate constant (kep, describing the redistribution of contrast agent from the interstitial into the intravascular compartment) in the biopsied region were calculated and compared with the histological and clinical data. Results DCE MRI parameters were significantly higher in lesions with marked infiltration than with mild or no infiltration (P < 0.05). The amplitude normalized to that in the iliac artery (An), but not kep, was higher in lesions with high vessel-density at histology (P = 0.01). Higher kep levels were found in presence of increased serum immunoglobulins. Conclusion Increased contrast uptake in the bone marrow of MM patients indicates at least moderate tumor involvement. Furthermore, the contrast enhancement correlates with vessel-density and serum markers of disease activity. J. Magn. Reson. Imaging 2005;22:154-162. © 2005 Wiley-Liss, Inc.