| |  Online-Ressource |
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| Verfasst von: | Mahtouk, Karène [VerfasserIn]  |
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| | Hose, Dirk [VerfasserIn] |
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| | Rème, Thierry [VerfasserIn] |
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| | De Vos, John [VerfasserIn] |
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| | Jourdan, Michel [VerfasserIn] |
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| | Moreaux, Jérôme [VerfasserIn] |
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| | Fiol, Geneviève [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Jourdan, Eric [VerfasserIn] |
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| | Grau, Véronique [VerfasserIn] |
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| | Moos, Marion [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Baudard, Marion [VerfasserIn] |
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| | Rossi, Jean François [VerfasserIn] |
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| | Cremer, Friedrich Walter [VerfasserIn] |
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| | Klein, Bernard [VerfasserIn] |
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| Titel: | Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells |
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| Verf.angabe: | Karène Mahtouk, Dirk Hose, Thierry Rème, John De Vos, Michel Jourdan, Jérôme Moreaux, Geneviève Fiol, Marc Raab, Eric Jourdan, Véronique Grau, Marion Moos, Hartmut Goldschmidt, Marion Baudard, Jean François Rossi, Friedrich W. Cremer, Bernard Klein |
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| E-Jahr: | 2005 |
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| Jahr: | 28 February 2005 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 25.02.2022 |
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| Titel Quelle: | Enthalten in: Oncogene |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 24(2005), 21 vom: Feb., Seite 3512-3524 |
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| ISSN Quelle: | 1476-5594 |
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| Abstract: | A hallmark of plasma cells is the expression of syndecan-1, which has major functions in epithelial cells, in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells. As amphiregulin (AREG) is another heparin-binding factor of the EGF family, we investigated its role in multiple myeloma (MM). Using Affymetrix DNA microarrays, we show here that the AREG gene was expressed by purified primary myeloma cells from 65 patients and that the expression was higher than in normal bone marrow (BM) plasma cells or plasmablastic cells. AREG stimulated IL-6 production and growth of BM stromal cells. Using real-time reverse transcriptase-polymerase chain reaction, we found that MM cells expressed ErbB receptors and that AREG promoted their growth. Furthermore, PD169540 (a pan-ErbB inhibitor) and IRESSA (an ErbB1-specific inhibitor) induced apoptosis of primary myeloma cells from 10/14 and 4/14 patients, respectively, and there was a synergistic effect with dexamethasone. Altogether, our data provide strong evidence that AREG plays an important role in the biology of MM and emphasize the advantages of using ErbB inhibitors, which might target myeloma cells as well as the tumor environment. |
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| DOI: | doi:10.1038/sj.onc.1208536 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.onc.1208536 |
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| | Volltext: https://www.nature.com/articles/1208536 |
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| | DOI: https://doi.org/10.1038/sj.onc.1208536 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Apoptosis |
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| | Cell Biology |
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| | general |
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| | Human Genetics |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1793907420 |
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| Verknüpfungen: | → Zeitschrift |
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Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells / Mahtouk, Karène [VerfasserIn]; 28 February 2005 (Online-Ressource)
