Duplication of chromosome arms 9q and 11q

• Verfasst von: Liebisch, Peter [VerfasserIn]
• Verfasst von: Scheck, Daniel [VerfasserIn]
• Verfasst von: Erné, Seiichi Alvise [VerfasserIn]
• Verfasst von: Wellmann, Alexander [VerfasserIn]
• Verfasst von: Wendl, Christiane [VerfasserIn]
• Verfasst von: Janczik, Sibylle [VerfasserIn]
• Verfasst von: Kolmus, Sonja [VerfasserIn]
• Verfasst von: Kröber, Alexander [VerfasserIn]
• Verfasst von: Einsele, Hermann [VerfasserIn]
• Verfasst von: Straka, Christian [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Benner, Axel [VerfasserIn]
• Verfasst von: Stilgenbauer, Stephan [VerfasserIn]
• Verfasst von: Döhner, Hartmut [VerfasserIn]
• Titel: Duplication of chromosome arms 9q and 11q
• Titelzusatz: Evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma
• Verf.angabe: Peter Liebisch, Daniel Scheck, Seiichi Alvise Erné, Alexander Wellmann, Christiane Wendl, Sibylle Janczik, Sonja Kolmus, Alexander Kröber, Hermann Einsele, Christian Straka, Hartmut Goldschmidt, Axel Benner, Stephan Stilgenbauer, Hartmut Döhner
• E-Jahr: 2005
• Jahr: [January 2005]
• Umfang: 4 S.
• Fussnoten: Published online 23 September 2004 in Wiley InterScience ; Gesehen am 25.02.2022
• Titel Quelle: Enthalten in: Genes, chromosomes & cancer
• Ort Quelle: New York, NY : Wiley-Liss, 1989
• Jahr Quelle: 2005
• Band/Heft Quelle: 42(2005), 1 vom: Jan., Seite 78-81
• ISSN Quelle: 1098-2264
• DOI: doi:10.1002/gcc.20098
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 179390930X

Abstract

14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a series of 108 MM patients using fluorescence in situ hybridization and DNA probes mapping to chromosome bands 1q21, 9q34, 11q25, 13q14, and 14q32. Three subsets of tumors were defined: (1) MM+/+ (detection of +9q and +11q; 43.5% of cases), (2) MM+/− (+9q or +11q; 21.3%), and (3) MM−/− (neither +9q nor +11q; 35.2%). The incidence of t(14q) was significantly different in these subgroups: 23% in MM+/+, 56% in MM+/−, and 89% in MM−/−. Deletion of 13q (13q−) also was significantly less frequent in MM+/+ (23%) than in MM+/− and MM−/− (36% and 63%, respectively). The nonrandom distribution of chromosomal aberrations in the present series of MM tumors points to a novel, 14q32 translocation-independent pathogenetic pathway in plasma cell neoplasms. © 2005 Wiley-Liss, Inc.