Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery

• Verfasst von: Kraus-Tiefenbacher, Uta [VerfasserIn]
• Verfasst von: Bauer, Lelia [VerfasserIn]
• Verfasst von: Scheda, Antonella [VerfasserIn]
• Verfasst von: Fleckenstein, Katharina [VerfasserIn]
• Verfasst von: Keller, Anke [VerfasserIn]
• Verfasst von: Herskind, Carsten [VerfasserIn]
• Verfasst von: Steil, Volker [VerfasserIn]
• Verfasst von: Melchert, Frank [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Titel: Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery
• Verf.angabe: Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Katharina Fleckenstein, Anke Keller, Carsten Herskind, Volker Steil, Frank Melchert, Frederik Wenz
• E-Jahr: 2006
• Jahr: 2 August 2006
• Umfang: 5 S.
• Fussnoten: Gesehen am 25.02.2022
• Titel Quelle: Enthalten in: International journal of radiation oncology, biology, physics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2006
• Band/Heft Quelle: 66(2006), 2, Seite 377-381
• ISSN Quelle: 1879-355X
• DOI: doi:10.1016/j.ijrobp.2006.05.042
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 20-year follow-up
• Sach-SW: boost
• Sach-SW: brachytherapy
• Sach-SW: breast cancer
• Sach-SW: cancer
• Sach-SW: cosmesis
• Sach-SW: dose-rate
• Sach-SW: intraoperative radiotherapy
• Sach-SW: iort
• Sach-SW: irradiation
• Sach-SW: late toxicity
• Sach-SW: lumpectomy
• Sach-SW: radiation-therapy
• Sach-SW: randomized trial
• Sach-SW: recurrence
• K10plus-PPN: 1793940541

Abstract

Purpose: Intraoperative radiotherapy (IORT) as a boost for breast cancer delivers a high single dose of radiation to a late-reacting tissue; therefore late toxicity is of particular interest, and long-term follow-up is warranted. To date there are only limited data available on breast cancer patients treated with IORT using low energy X-rays. We analyzed toxicity and cosmesis after IORT as a boost with a minimum follow-up of 18 months. Methods and Materials: A total of 73 patients treated with IORT (20 Gy/50 kV X-rays; INTRABEAM [Carl Zeiss Surgical, Oberkochen, Germany]) to the tumor bed during breast-conserving surgery as a boost followed by whole-breast radiotherapy (WBRT, 46 Gy) underwent a prospective, predefined follow-up (median, 25 months; range 18 44 months), including clinical examination and breast ultrasound at 6-months and mammographies at 1-year intervals. Toxicities were documented using the common toxicity criteria (CTC)/European Organization for Research and Treatment of Cancer and the LENT-SOMA score. Cosmesis was evaluated with a score from I to 4. Results: The IORT in combination with WBRT was well tolerated, with no Grade 3 or 4 skin toxicities and no telangiectasias. Fibrosis of the entire breast was observed in 5% of the patients. A circumscribed fibrosis around the tumor bed was palpable in up to 27% with a peak around 18 months after therapy and a decline thereafter. The observed toxicitiy rates were not influenced by age, tumor stage, or systemic therapy. The cosmetic outcome was good to excellent in >= 90% of cases. Conclusions: After IORT of the breast using low-energy X-rays, no unexpected toxicity rates were observed during long-term-follow-up. (c) 2006 Elsevier Inc.