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| Verfasst von: | Zeier, Martin [VerfasserIn]  |
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| | Dengler, Jolanta [VerfasserIn] |
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| | Linke, Reinhold P. [VerfasserIn] |
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| | Donini, Ugo [VerfasserIn] |
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| | Waldherr, Rüdiger [VerfasserIn] |
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| | Andrassy, Konrad [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| Titel: | No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement |
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| Verf.angabe: | Martin Zeier, Jolanta Perz, Reinhold P. Linke, Ugo Donini, Rüdiger Waldherr, Konrad Andrassy, Anthony D. Ho, Hartmut Goldschmidt |
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| E-Jahr: | 2003 |
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| Jahr: | [December 2003] |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 25.02.2022 |
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| Titel Quelle: | Enthalten in: Nephrology, dialysis, transplantation |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1986 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 18(2003), 12 vom: Dez., Seite 2644-2647 |
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| ISSN Quelle: | 1460-2385 |
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| Abstract: | Background. High-dose chemotherapy followed by autologous blood stem cell transplantation induces remission of plasma cell dyscrasia in patients with AL amyloidosis. The impact of this treatment on the glomerular amyloid mass is still unknown.Methods. In the present study, the quantity of the renal amyloid mass before and more than 3 years after high-dose melphalan treatment and autologous blood stem cell transplantation was assessed in two patients. At the time of the second renal biopsy, both patients were in complete remission without detectable serum and urinary monocloncal IgA-λ and a normal percentage of plasma cells in the bone marrow.Results. In both patients with biopsy-proven AL amyloidosis, urinary protein excretion decreased from 7 g/24 h to <2 g/24 h more than 3 years after autologous blood stem cell transplantation. In contrast, glomerular amyloid deposits persisted, as shown in the second biopsy.Conclusion. Despite complete remission of the plasma cell dyscrasia and improvement of glomerular permeability, the amount of glomerular amyloid mass did not regress. |
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| DOI: | doi:10.1093/ndt/gfg436 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/ndt/gfg436 |
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| | DOI: https://doi.org/10.1093/ndt/gfg436 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1793956375 |
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| Verknüpfungen: | → Zeitschrift |
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No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement / Zeier, Martin [VerfasserIn]; [December 2003] (Online-Ressource)
