| |  Online-Ressource |
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| Verfasst von: | Harris, Lachlan [VerfasserIn]  |
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| | Rigo, Piero [VerfasserIn] |
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| | Stiehl, Thomas [VerfasserIn] |
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| | Gaber, Zachary B. [VerfasserIn] |
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| | Austin, Sophie H. L. [VerfasserIn] |
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| | Masdeu, Maria del Mar [VerfasserIn] |
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| | Edwards, Amelia [VerfasserIn] |
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| | Urbán, Noelia [VerfasserIn] |
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| | Marciniak-Czochra, Anna [VerfasserIn] |
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| | Guillemot, François [VerfasserIn] |
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| Titel: | Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population |
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| Verf.angabe: | Lachlan Harris, Piero Rigo, Thomas Stiehl, Zachary B. Gaber, Sophie H.L. Austin, Maria del Mar Masdeu, Amelia Edwards, Noelia Urbán, Anna Marciniak-Czochra, and François Guillemot |
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| E-Jahr: | 2021 |
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| Jahr: | February 12, 2021 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 28.02.2022 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 28(2021), 5 vom: 6. Mai, Seite 863-876,e1-e6 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this stabilization of stem cell numbers in young adults is the result of coordinated changes in stem cell behavior. Although proliferating neural stem cells in juveniles differentiate rapidly, they increasingly return to a resting state of shallow quiescence and progress through additional self-renewing divisions in adulthood. Single-cell transcriptomics, modeling, and label retention analyses indicate that resting cells have a higher activation rate and greater contribution to neurogenesis than dormant cells, which have not left quiescence. These changes in stem cell behavior result from a progressive reduction in expression of the pro-activation protein ASCL1 because of increased post-translational degradation. These cellular mechanisms help reconcile current contradictory models of hippocampal neural stem cell (NSC) dynamics and may contribute to the different rates of decline of hippocampal neurogenesis in mammalian species, including humans. |
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| DOI: | doi:10.1016/j.stem.2021.01.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.stem.2021.01.003 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1934590921000035 |
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| | DOI: https://doi.org/10.1016/j.stem.2021.01.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | age |
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| | Ascl1 |
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| | dormant |
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| | hippocampus |
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| | Huwe1 |
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| | neural stem cell |
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| | neurogenesis |
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| | quiescence |
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| | resting |
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| K10plus-PPN: | 1794001190 |
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| Verknüpfungen: | → Zeitschrift |
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Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population / Harris, Lachlan [VerfasserIn]; February 12, 2021 (Online-Ressource)
