Soluble urokinase receptor and mortality in kidney transplant recipients

• Verfasst von: Morath, Christian [VerfasserIn]
• Verfasst von: Hayek, Salim [VerfasserIn]
• Verfasst von: Döhler, Bernd [VerfasserIn]
• Verfasst von: Nußhag, Christian [VerfasserIn]
• Verfasst von: Sommerer, Claudia [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Reiser, Jochen [VerfasserIn]
• Verfasst von: Süsal, Caner [VerfasserIn]
• Titel: Soluble urokinase receptor and mortality in kidney transplant recipients
• Verf.angabe: Christian Morath, Salim S. Hayek, Bernd Döhler, Christian Nusshag, Claudia Sommerer, Martin Zeier, Jochen Reiser and Caner Süsal
• E-Jahr: 2022
• Jahr: 03 February 2022
• Umfang: 8 S.
• Fussnoten: Gesehen am 01.03.2022
• Titel Quelle: Enthalten in: Transplant international
• Ort Quelle: Lausanne : Frontiers Media, 1988
• Jahr Quelle: 2022
• Band/Heft Quelle: 35(2022) vom: 3. Feb., Artikel-ID 10071, Seite 1-8
• ISSN Quelle: 1432-2277
• DOI: doi:10.3389/ti.2021.10071
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1794122079
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Main problem: Soluble urokinase plasminogen activator receptor (suPAR) is an immunological risk factor for kidney disease and a prognostic marker for cardiovascular events. Methods: We measured serum suPAR levels in a total of 1,023 kidney transplant recipients either before (cohort 1, n=474) or at year 1 after transplantation (cohort 2, n=549). The association of suPAR levels and all-cause and cardiovascular mortality was evaluated by multivariable Cox regression analysis. Results: The highest suPAR tertile compared to the two lower tertiles had a significantly higher risk of all-cause mortality in both cohorts separately (cohort 1: hazard ratio (HR) 1.92, 95% confidence interval (CI) 1.20-3.08, P=0.007; cohort 2: HR=2.78, 95% CI 1.51-5.13, P=0.001) and combined (n=1,023, combined HR=2.14, 95% CI 1.48-3.08, P<0.001). The association remained significant in the subgroup of patients with normal kidney function (cohort 2: HR=5.40, 95% CI 1.42-20.5, P=0.013). The increased mortality risk in patients with high suPAR levels was attributable mainly to an increased rate of cardiovascular death (n=1,023, HR=4.24, 95% CI 1.81-9.96, P<0.001). Conclusions: A high suPAR level prior to and at 1 year after kidney transplantation was associated with an increased risk of patient death independent of kidney function, predominantly from cardiovascular cause.