Outpatient treatment of multiple myeloma with a combination of vincristine, Adriamycin and dexamethasone

• Verfasst von: Egerer, Gerlinde [VerfasserIn]
• Verfasst von: Hegenbart, Ute [VerfasserIn]
• Verfasst von: Salwender, Hans [VerfasserIn]
• Verfasst von: Haas, R. [VerfasserIn]
• Verfasst von: Hahn, U. [VerfasserIn]
• Verfasst von: Schmier, Johann-Wilhelm Adam [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Titel: Outpatient treatment of multiple myeloma with a combination of vincristine, Adriamycin and dexamethasone
• Verf.angabe: G. Egerer, U. Hegenbart, H. Salwender, R. Haas, U. Hahn, J. Schmier, A. Ho, H. Goldschmidt
• E-Jahr: 2001
• Jahr: [July 2001]
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Published online: 21 March 2001 ; Gesehen am 01.03.2022
• Titel Quelle: Enthalten in: Supportive care in cancer
• Ort Quelle: Berlin : Springer, 1993
• Jahr Quelle: 2001
• Band/Heft Quelle: 9(2001), 5 vom: Juli, Seite 380-385
• ISSN Quelle: 1433-7339
• DOI: doi:10.1007/s005200000224
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1794158073

Abstract

Patients with relapsed multiple myeloma (MM) have been shown to respond to a combination therapy consisting of vincristine, Adriamycin (doxorubicin) and high-dose dexamethasone (VAD). Because of the low hematological toxicity of the VAD regimen, this combination is frequently chosen for tumor reduction prior to high-dose therapy and blood stem cell transplantation. This study was designed to examine the efficacy and complications of outpatient VAD treatment. Over a period of 6 years, 103 outpatients with MM were treated with VAD chemotherapy administered by microprocessor-controlled infusion pumps via intravenous polyurethane catheters equipped with a safety valve. Response to treatment, treatment-associated complications and infections were documented and analyzed. In 85 of the 103 patients, tumor reduction by more than 25% was found. In 8 patients an occlusion occurred as a result of kinking of the central venous catheter in the subcutaneous segment. In two treatment cycles the infusions had to be stopped because of irreversible catheter occlusion. Twenty patients were hospitalized because of complications, which were infectious in 12 and noninfectious in 8. Severe infectious complications (≥ WHO grade III) occurred in 5.6% of the treatment cycles. Thus, continuous infusion of VAD over 96 h can be performed on an outpatient basis with a low complication rate.