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| Verfasst von: | Waldmann, Volker [VerfasserIn]  |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Jäckel, Andreas [VerfasserIn] |
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| | Deichmann, Martin [VerfasserIn] |
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| | Hegenbart, Ute [VerfasserIn] |
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| | Hartschuh, Wolfgang [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Näher, Helmut [VerfasserIn] |
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| Titel: | Transient complete remission of metastasized Merkel cell carcinoma by high-dose polychemotherapy and autologous peripheral blood stem cell transplantation |
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| Verf.angabe: | V. Waldmann, H. Goldschmidt, A. Jäckel, M. Deichmann, U. Hegenbart, W. Hartschuh, A. Ho and H. Näher |
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| E-Jahr: | 2000 |
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| Jahr: | [2000] |
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| Umfang: | 3 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 01.03.2022 |
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| Titel Quelle: | Enthalten in: British journal of dermatology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1892 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 143(2000), 4, Seite 837-839 |
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| ISSN Quelle: | 1365-2133 |
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| Abstract: | Merkel cell carcinoma (MCC) is a rare cutaneous tumour with neuroendocrine differentiation. Metastasis occurs preferentially to regional lymph nodes but distant and multiple visceral metastases may occur. Chemotherapy has been performed with a variety of protocols based largely on agents active in small-cell lung cancer. Owing to the rarity of MCC, there is no standard protocol for the treatment of metastatic disease. We report a 59-year-old patient with systemic metastatic MCC. After diagnosis of distant metastases, first-line polychemotherapy (cisplatin 80 mg m−2, doxorubicin 50 mg m−2, etoposide 300 mg m−2 and bleomycin 30 mg) was administered four times at 3-weekly intervals and resulted in partial remission of metastases. Subsequently, high-dose chemotherapy according to the PEI regimen (ifosfamide 12 g m−2, carboplatin 900 mg m−2 and etoposide 1500 mg m−2) was applied, followed by autologous blood stem cell transplantation (ABSCT). This protocol resulted in a complete remission that lasted for 6 months. This is the first report on a complete remission of metastatic MCC after high-dose polychemotherapy and ABSCT. High-dose chemotherapy might be a therapeutic option in chemosensitive metastatic MCC, and further evaluation is warranted. |
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| DOI: | doi:10.1046/j.1365-2133.2000.03852.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1046/j.1365-2133.2000.03852.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2133.2000.03852.x |
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| | DOI: https://doi.org/10.1046/j.1365-2133.2000.03852.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chemotherapy |
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| | Merkel cell carcinoma |
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| | stem cell transplantation |
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| K10plus-PPN: | 1794171045 |
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| Verknüpfungen: | → Zeitschrift |
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Transient complete remission of metastasized Merkel cell carcinoma by high-dose polychemotherapy and autologous peripheral blood stem cell transplantation / Waldmann, Volker [VerfasserIn]; [2000] (Online-Ressource)
