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| Verfasst von: | Karimian-Jazi, Kianush [VerfasserIn]  |
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| | Neuberger, Ulf [VerfasserIn] |
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| | Schregel, Katharina [VerfasserIn] |
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| | Brugnara, Gianluca [VerfasserIn] |
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| | Schwarz, Daniel [VerfasserIn] |
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| | Jäger, Laura Bettina [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Breckwoldt, Michael O. [VerfasserIn] |
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| Titel: | Diagnostic value of gadolinium contrast administration for spinal cord magnetic resonance imaging in multiple sclerosis patients and correlative markers of lesion enhancement |
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| Verf.angabe: | Kianush Karimian-Jazi, Ulf Neuberger, Katharina Schregel, Gianluca Brugnara, Daniel Schwarz, Laura Bettina Jäger, Wolfgang Wick, Martin Bendszus and Michael O. Breckwoldt |
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| Jahr: | 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Issue published: October 1, 2021 ; Gesehen am 01.03.2022 |
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| Titel Quelle: | Enthalten in: Multiple sclerosis journal - experimental, translational and clinical |
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| Ort Quelle: | London : Sage Publishing, 2015 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 7(2021), 4 vom: Okt./Dez., Artikel-ID 20552173211047978, Seite 1-9 |
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| ISSN Quelle: | 2055-2173 |
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| Abstract: | BackgroundMagnetic resonance imaging is essential for monitoring people with multiple sclerosis, but the diagnostic value of gadolinium contrast administration in spine magnetic resonance imaging is unclear.ObjectiveTo assess the diagnostic value of gadolinium contrast administration in spine magnetic resonance imaging follow-up examinations and identify imaging markers correlating with lesion enhancement.MethodsA total of 65 multiple sclerosis patients with at least 2 spinal magnetic resonance imaging follow-up examinations were included. Spine magnetic resonance imaging was performed at 3 Tesla with a standardized protocol (sagittal and axial T2-weighted turbo spin echo and T1-weighted post-contrast sequences). T2 lesion load and enhancing lesions were assessed by two independent neuroradiologists for lesion size, localization, and T2 signal ratio (T2 signallesion/T2 signalnormal appearing spinal cord).ResultsA total of 68 new spinal T2 lesions and 20 new contrast-enhancing lesions developed during follow-up. All enhancing lesions had a discernable correlate as a new T2 lesion. Lesion enhancement correlated with a higher T2 signal ratio compared to non-enhancing lesions (T2 signal ratio: 2.0?±?0.4 vs. 1.4?±?0.2, ****p < 0.001). Receiver operating characteristics analysis showed an optimal cutoff value of signal ratio 1.78 to predict lesion enhancement (82% sensitivity and 97% specificity).ConclusionGadolinium contrast administration is dispensable in follow-up spine magnetic resonance imaging if no new T2 lesions are present. Probability of enhancement correlates with the T2 signal ratio. |
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| DOI: | doi:10.1177/20552173211047978 |
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| URL: | kostenfrei: Volltext ; Verlag: https://doi.org/10.1177/20552173211047978 |
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| | kostenfrei: Volltext: https://journals.sagepub.com/doi/10.1177/20552173211047978 |
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| | DOI: https://doi.org/10.1177/20552173211047978 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | gadolinium depositions |
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| | gadolinium-based contrast agents |
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| | Multiple sclerosis |
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| | spinal magnetic resonance imaging |
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| | T2 signal ratio |
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| K10plus-PPN: | 179418659X |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Diagnostic value of gadolinium contrast administration for spinal cord magnetic resonance imaging in multiple sclerosis patients and correlative markers of lesion enhancement / Karimian-Jazi, Kianush [VerfasserIn]; 2021 (Online-Ressource)
