Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Rose, Marcel [VerfasserIn]  |
|---|
| | Domsch, Katrin [VerfasserIn] |
|---|
| | Bartle-Schultheis, Jakob [VerfasserIn] |
|---|
| | Reim, Ingolf [VerfasserIn] |
|---|
| | Schaub, Christoph [VerfasserIn] |
|---|
| Titel: | Twist regulates Yorkie activity to guide lineage reprogramming of syncytial alary muscles |
|---|
| Verf.angabe: | Marcel Rose, Katrin Domsch, Jakob Bartle-Schultheis, Ingolf Reim, Christoph Schaub |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | January 25, 2022 |
|---|
| Umfang: | 18 S. |
|---|
| Fussnoten: | Gesehen am 02.03.2022 |
|---|
| Titel Quelle: | Enthalten in: Cell reports |
|---|
| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 38(2022), 4, Artikel-ID 110295, Seite 1-18 |
|---|
| ISSN Quelle: | 2211-1247 |
|---|
| Abstract: | Genesis of syncytial muscles is typically considered as a paradigm for an irreversible developmental process. Notably, transdifferentiation of syncytial muscles is naturally occurring during Drosophila development. The ventral longitudinal heart-associated musculature (VLM) arises by a unique mechanism that revokes differentiation states of so-called alary muscles and comprises at least two distinct steps: syncytial muscle cell fragmentation into single myoblasts and successive reprogramming into founder cells that orchestrate de novo fiber formation of the VLM lineage. Here, we provide evidence that the mesodermal master regulator twist plays a key role during this reprogramming process. Acting downstream of Drosophila Tbx1 (Org-1), Twist is regulating the activity of the Hippo pathway effector Yorkie and is required for the initiation of syncytial muscle dedifferentiation and fragmentation. Subsequently, fibroblast growth factor receptor (FGFR)-Ras-mitogen-activated protein kinase (MAPK) signaling in resulting mononucleated myoblasts maintains Twist expression, thereby stabilizing nuclear Yorkie activity and inducing their lineage switch into founder cells of the VLM. |
|---|
| DOI: | doi:10.1016/j.celrep.2022.110295 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2022.110295 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722000018 |
|---|
| | DOI: https://doi.org/10.1016/j.celrep.2022.110295 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | FGFR |
|---|
| | lineage plasticity |
|---|
| | muscle |
|---|
| | reprogramming |
|---|
| | Twist |
|---|
| | Yorkie |
|---|
| K10plus-PPN: | 179437633X |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Twist regulates Yorkie activity to guide lineage reprogramming of syncytial alary muscles / Rose, Marcel [VerfasserIn]; January 25, 2022 (Online-Ressource)
68884374
