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| Verfasst von: | Hanna, Bola [VerfasserIn]  |
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| | Llaó Cid, Laura [VerfasserIn] |
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| | ̇Iskar, Murat [VerfasserIn] |
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| | Rößner, Philipp M. [VerfasserIn] |
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| | Klett, Lara C. [VerfasserIn] |
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| | Wong, John K. L. [VerfasserIn] |
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| | Paul, Yashna [VerfasserIn] |
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| | Ioannou, Nikolaos [VerfasserIn] |
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| | Öztürk, Selcen [VerfasserIn] |
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| | Mack, Norman [VerfasserIn] |
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| | Kalter, Verena [VerfasserIn] |
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| | Colomer, Dolors [VerfasserIn] |
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| | Campo, Elías [VerfasserIn] |
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| | Bloehdorn, Johannes [VerfasserIn] |
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| | Stilgenbauer, Stephan [VerfasserIn] |
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| | Dietrich, Sascha [VerfasserIn] |
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| | Schmidt, Manfred [VerfasserIn] |
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| | Gabriel, Richard [VerfasserIn] |
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| | Rippe, Karsten [VerfasserIn] |
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| | Feuerer, Markus [VerfasserIn] |
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| | Ramsay, Alan G. [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Zapatka, Marc [VerfasserIn] |
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| | Seiffert, Martina [VerfasserIn] |
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| Titel: | Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity |
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| Verf.angabe: | Bola S. Hanna, Laura Llaó-Cid, Murat Iskar, Philipp M. Roessner, Lara C. Klett, John K. L. Wong, Yashna Paul, Nikolaos Ioannou, Selcen Öztürk, Norman Mack, Verena Kalter, Dolors Colomer, Elías Campo, Johannes Bloehdorn, Stephan Stilgenbauer, Sascha Dietrich, Manfred Schmidt, Richard Gabriel, Karsten Rippe, Markus Feuerer, Alan G. Ramsay, Peter Lichter, Marc Zapatka, Martina Seiffert |
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| E-Jahr: | 2021 |
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| Jahr: | December 14, 2021 |
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| Umfang: | 28 S. |
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| Fussnoten: | Gesehen am 02.03.2022 ; Im Titel sind "int" und "+" hochgestellt |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 54(2021), 12, Seite 2825-2841 |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1hi, functionally impaired CD8+ T cells that accumulated in secondary lymphoid organs during disease progression and a functionally competent PD-1int subset. Frequencies of PD-1int TCF-1+ CD8+ T cells decreased upon Il10rb or Stat3 deletion, leading to accumulation of PD-1hi cells and accelerated tumor progression. Mechanistically, inhibition of IL-10R signaling altered chromatin accessibility and disrupted cooperativity between the transcription factors NFAT and AP-1, promoting a distinct NFAT-associated program. Low IL10 expression or loss of IL-10R-STAT3 signaling correlated with increased frequencies of exhausted CD8+ T cells and poor survival in CLL and in breast cancer patients. Thus, balance between PD-1hi, exhausted CD8+ T cells and functional PD-1int TCF-1+ CD8+ T cells is regulated by cell-intrinsic IL-10R signaling, with implications for immunotherapy. |
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| DOI: | doi:10.1016/j.immuni.2021.11.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.immuni.2021.11.004 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1074761321004957 |
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| | DOI: https://doi.org/10.1016/j.immuni.2021.11.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CD8 T cells |
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| | CLL |
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| | IL-10 |
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| | IL-10R |
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| | NFAT |
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| | PD-1 heterogeneity |
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| | STAT3 |
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| | T cell exhaustion |
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| | TCF-1 |
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| | tumor microenvironment |
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| K10plus-PPN: | 1794408541 |
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| Verknüpfungen: | → Zeitschrift |
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Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity / Hanna, Bola [VerfasserIn]; December 14, 2021 (Online-Ressource)
