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Verfasst von:Weis, Meike [VerfasserIn]   i
 Nazari, Sosan [VerfasserIn]   i
 Perez Ortiz, Alba [VerfasserIn]   i
 Nowak, Oliver Claudius [VerfasserIn]   i
 Hetjens, Svetlana [VerfasserIn]   i
 Zahn, Katrin [VerfasserIn]   i
 Schönberg, Stefan [VerfasserIn]   i
 Schaible, Thomas [VerfasserIn]   i
 Rafat, Neysan [VerfasserIn]   i
Titel:The chest radiographic thoracic area can serve as a prediction marker for morbidity and mortality in infants with congenital diaphragmatic hernia
Verf.angabe:Meike Weis, Sosan Burhany, Alba Perez Ortiz, Oliver Nowak, Svetlana Hetjens, Katrin Zahn, Stefan Schoenberg, Thomas Schaible and Neysan Rafat
E-Jahr:2021
Jahr:23 December 2021
Umfang:11 S.
Fussnoten:Gesehen am 03.03.2022
Titel Quelle:Enthalten in: Frontiers in Pediatrics
Ort Quelle:Lausanne : Frontiers Media, 2013
Jahr Quelle:2021
Band/Heft Quelle:9(2021) vom: 23. Dez., Artikel-ID 740941, Seite 1-11
ISSN Quelle:2296-2360
Abstract:Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR).Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD).Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR.Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR.
URL:kostenfrei: Volltext: https://doi.org/10.3389/fped.2021.740941
 kostenfrei: Volltext: https://www.frontiersin.org/article/10.3389/fped.2021.740941
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1794601031
Verknüpfungen:→ Zeitschrift
 
 
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