Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Machiraju, Devayani [VerfasserIn]  |
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| | Schäfer, Sarah [VerfasserIn] |
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| | Hassel, Jessica C. [VerfasserIn] |
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| Titel: | Potential reasons for unresponsiveness to anti-PD1 immunotherapy in young patients with advanced melanoma |
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| Verf.angabe: | Devayani Machiraju, Sarah Schäfer, Jessica C. Hassel |
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| E-Jahr: | 2021 |
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| Jahr: | 30 November 2021 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 04.03.2022 |
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| Titel Quelle: | Enthalten in: Life |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021), 12, Artikel-ID 1318, Seite 1-17 |
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| ISSN Quelle: | 2075-1729 |
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| Abstract: | The impact of age on the clinical benefit of anti-PD1 immunotherapy in advanced melanoma patients has been evolving recently. Due to a reduced immune function in elderly patients, young patients with a robust immune system are theoretically expected to benefit more from the treatment approach. However, in contrast to this hypothesis, recent studies in patients with metastatic melanoma have demonstrated that immunotherapy, especially with anti-PD1 treatment, is less effective in patients below 65 years, on average, with significantly lower responses and reduced overall survival compared to patients above 65 years of age. Besides, data on young patients are even more sparse. Hence, in this review, we will focus on age-dependent differences in the previously described resistance mechanisms to the treatment and discuss the development of potential combination treatment strategies for enhancing the anti-tumor efficacy of anti-PD1 or PDL1 treatment in young melanoma patients. |
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| DOI: | doi:10.3390/life11121318 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: https://doi.org/10.3390/life11121318 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2075-1729/11/12/1318 |
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| | DOI: https://doi.org/10.3390/life11121318 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | age |
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| | gender |
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| | gut microbiome |
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| | immunotherapy |
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| | melanoma |
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| | radiation |
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| | stress |
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| | Tregs |
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| | tumor antigenicity |
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| | vaccination |
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| K10plus-PPN: | 179469854X |
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| Verknüpfungen: | → Zeitschrift |
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Potential reasons for unresponsiveness to anti-PD1 immunotherapy in young patients with advanced melanoma / Machiraju, Devayani [VerfasserIn]; 30 November 2021 (Online-Ressource)
68891630
