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Verfasst von:Zahn, Katrin [VerfasserIn]   i
 Schaible, Thomas [VerfasserIn]   i
 Rafat, Neysan [VerfasserIn]   i
 Weis, Meike [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Wessel, Lucas [VerfasserIn]   i
Titel:Longitudinal follow-up with radiologic screening for recurrence and secondary hiatal hernia in neonates with open repair of congenital diaphragmatic hernia
Titelzusatz:a large prospective, observational cohort study at one referral center
Verf.angabe:Katrin B. Zahn, Thomas Schaible, Neysan Rafat, Meike Weis, Christel Weiss and Lucas Wessel
Jahr:2021
Umfang:12 S.
Fussnoten:Gesehen am 04.03.2022
Titel Quelle:Enthalten in: Frontiers in Pediatrics
Ort Quelle:Lausanne : Frontiers Media, 2013
Jahr Quelle:2021
Band/Heft Quelle:9(2021) vom: 17. Dez., Artikel-ID 796478, Seite 1-12
ISSN Quelle:2296-2360
Abstract:Objective: After neonatal repair of congenital diaphragmatic hernia (CDH) recurrence is the most severe surgical complication and reported in up to 50% after patch implantation. Previous studies are difficult to compare due to differences in surgical techniques and retrospective study design and lack of standardized follow-up or radiologic imaging. The aim was to reliably detect complication rates by radiologic screening during longitudinal follow-up after neonatal open repair of CDH and to determine possible risk factors.Methods: At our referral center with standardized treatment algorithm and follow-up program, consecutive neonates were screened for recurrence by radiologic imaging at defined intervals during a 12-year period.Results: 326 neonates with open CDH repair completed follow-up of a minimum of 2 years. 68 patients (21%) received a primary repair, 251 (77%) a broad cone-shaped patch, and 7 a flat patch (2%). Recurrence occurred in 3 patients (0.7%) until discharge and diaphragmatic complications in 28 (8.6%) thereafter. Overall, 38 recurrences and/or secondary hiatal hernias were diagnosed (9% after primary repair, 12.7% after cone-shaped patch; p = 0.53). Diaphragmatic complications were significantly associated with initial defect size (r = 0.26). In multivariate analysis left-sided CDH, an abdominal wall patch and age below 4 years were identified as independent risk factors. Accordingly, relative risks (RRs) were significantly increased [left-sided CDH: 8.5 (p = 0.03); abdominal wall patch: 3.2 (p < 0.001); age ≤4 years: 6.5 (p < 0.002)]. 97% of patients with diaphragmatic complications showed no or nonspecific symptoms and 45% occurred beyond 1 year of age.Conclusions: The long-term complication rate after CDH repair highly depends on surgical technique: a comparatively low recurrence rate seems to be achievable in large defects by implantation of a broad cone-shaped, non-absorbable patch. Longitudinal follow-up with regular radiologic imaging until adolescence is essential to reliably detecting recurrence to prevent acute incarceration and chronic gastrointestinal morbidity with their impact on prognosis. Based on our findings and literature review, a risk-stratified approach to diaphragmatic complications is proposed.
DOI:doi:10.3389/fped.2021.796478
URL:kostenfrei: Volltext: https://doi.org/10.3389/fped.2021.796478
 kostenfrei: Volltext: https://www.frontiersin.org/article/10.3389/fped.2021.796478
 DOI: https://doi.org/10.3389/fped.2021.796478
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:179471359X
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