Publication rate and research topics of studies in pediatric kidney transplantation

• Verfasst von: Patry, Christian [VerfasserIn]
• Verfasst von: Cordts, Stephanie E. [VerfasserIn]
• Verfasst von: Baumann, Lukas [VerfasserIn]
• Verfasst von: Höcker, Britta [VerfasserIn]
• Verfasst von: Fichtner, Alexander [VerfasserIn]
• Verfasst von: Ries, Markus [VerfasserIn]
• Verfasst von: Tönshoff, Burkhard [VerfasserIn]
• Titel: Publication rate and research topics of studies in pediatric kidney transplantation
• Verf.angabe: Christian Patry, Stefanie Cordts, Lukas Baumann, Britta Höcker, Alexander Fichtner, Markus Ries, Burkhard Tönshoff
• E-Jahr: 2022
• Jahr: 07 March 2022
• Umfang: 11 S.
• Fussnoten: Gesehen am 08.03.2022
• Titel Quelle: Enthalten in: Pediatric transplantation
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1999
• Jahr Quelle: 2022
• Band/Heft Quelle: (2022), Artikel-ID e14262, Seite 1-11
• ISSN Quelle: 1399-3046
• DOI: doi:10.1111/petr.14262
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: pediatric kidney transplantation
• Sach-SW: publication bias
• Sach-SW: publication rate
• Sach-SW: sponsoring
• Sach-SW: time to publication
• K10plus-PPN: 1794960244
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

BACKGROUND: The quality of medical care for pediatric kidney transplant recipients depends on sound evidence from published clinical trials. - METHODS: We examined the publication rate, time to publication, and factors associated with publication of studies in pediatric kidney transplantation registered on ClinicalTrials.gov from 1999 to 2020. - RESULTS: We identified 136 studies with an overall enrollment of 36255 study participants, of which only 58.8% have been published yet. Unpublished studies included data from 14 350 participants. The median time to publication was 25 months (range, 0-117) with a significantly shorter time to publication in more recent years. The most frequently investigated research topic was immunosuppressants (49.3%), followed by perioperative management (11.0%) and infectiology (10.3%). The percentage of published studies was highest for the topic steroid withdrawal (87.5%), followed by infectiology (78.6%), and nutrition, sports and quality of life (71.4%). Studies, which were co-funded by industry, showed a significantly higher 5-year publication rate (p = 0.019). - CONCLUSIONS: In conclusion, nearly half of all studies in pediatric kidney transplantation remain unpublished. Non-publication of studies might lead to a publication bias with a negative impact on clinical decision-making.