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| Verfasst von: | Hucl, Tomas [VerfasserIn]  |
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| | Kylanpää, Marja-Leena [VerfasserIn] |
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| | Künzli, Beat [VerfasserIn] |
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| | Witt, Heiko B. G. [VerfasserIn] |
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| | Lempinen, Marko [VerfasserIn] |
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| | Schneider, Alexander [VerfasserIn] |
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| | Kemppainen, Esko [VerfasserIn] |
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| | Löhr, J.-Matthias [VerfasserIn] |
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| | Haas, Stephan [VerfasserIn] |
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| | Friess, Helmut [VerfasserIn] |
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| | Ockenga, Johann [VerfasserIn] |
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| | Rosendahl, Jonas [VerfasserIn] |
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| | Schulz, Hans-Ulrich [VerfasserIn] |
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| | Gress, Thomas [VerfasserIn] |
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| | Singer, Manfred V. [VerfasserIn] |
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| | Pfützer, Roland [VerfasserIn] |
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| Titel: | Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis |
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| Verf.angabe: | Tomas Hucl, Marja-Leena Kylanpää, Beat Künzli, Heiko Witt, Marko Lempinen, Alexander Schneider, Esko Kemppainen, Matthias Löhr, Stephan L. Haas, Helmut Friess, Johann Ockenga, Jonas Rosendahl, Hans-Ulrich Schulz, Thomas Gress, Manfred V. Singer and Roland H. Pfützer |
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| Jahr: | 2009 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 08.03.2022 |
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| Titel Quelle: | Enthalten in: European journal of gastroenterology & hepatology |
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| Ort Quelle: | Hagerstown, Md. : Lippincott Williams & Wilkins, 1989 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 21(2009), 9, Seite 1032-1035 |
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| ISSN Quelle: | 1473-5687 |
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| Abstract: | Background - Reduction in angiotensin-converting enzyme (ACE) activity has been shown to attenuate pancreatic stellate cell activation and pancreatic fibrosis and suggested as a potential treatment for chronic pancreatitis. The ACE gene insertion/deletion (I/D) polymorphism in intron 16 accounts for nearly half the variation in serum ACE levels. This study determined the frequency of the I/D polymorphism in patients with acute and chronic pancreatitis. - Methods - In total, 887 patients (346 with alcoholic, 443 with nonalcoholic, and 98 with acute pancreatitis) were enrolled, and were compared with 1294 healthy controls. Genotyping of the I/D polymorphism was performed by PCR or melting curve analyses. - Results - No significant differences were found in the prevalence of the ACE-deletion genotype frequencies when patients with alcoholic (27.5%), nonalcoholic (26.4%), and acute pancreatitis (32.7%) were compared with controls (26.9%). Likewise, allele frequencies of the ACE deletion polymorphism were not significantly different in patients with alcoholic (53.8%), nonalcoholic (50.6%), and acute pancreatitis (54.1%) and controls (52.7%). - Conclusion - The I/D polymorphism of the ACE gene was not found to be associated with acute and chronic pancreatitis. |
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| DOI: | doi:10.1097/MEG.0b013e328326f586 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/MEG.0b013e328326f586 |
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| | Volltext: https://journals.lww.com/eurojgh/Fulltext/2009/09000/Angiotensin_converting_enzyme_insertion_deletion.11.aspx |
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| | DOI: https://doi.org/10.1097/MEG.0b013e328326f586 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Hucl, Tomas: Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis. - 2009 |
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| K10plus-PPN: | 1794970355 |
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| Verknüpfungen: | → Zeitschrift |
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Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis / Hucl, Tomas [VerfasserIn]; 2009 (Online-Ressource)
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