| |  Online-Ressource |
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| Verfasst von: | Lin, Jing-wen [VerfasserIn]  |
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| | Meireles, Patrícia [VerfasserIn] |
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| | Prudêncio, Miguel [VerfasserIn] |
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| | Engelmann, Sabine [VerfasserIn] |
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| | Annoura, Takeshi [VerfasserIn] |
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| | Sajid, Mohammed [VerfasserIn] |
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| | Chevalley-Maurel, Séverine [VerfasserIn] |
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| | Ramesar, Jai [VerfasserIn] |
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| | Nahar, Carolin [VerfasserIn] |
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| | Avramut, Cristina M. C. [VerfasserIn] |
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| | Koster, Abraham J. [VerfasserIn] |
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| | Matuschewski, Kai [VerfasserIn] |
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| | Waters, Andrew P. [VerfasserIn] |
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| | Janse, Chris J. [VerfasserIn] |
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| | Mair, Gunnar R. [VerfasserIn] |
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| | Khan, Shahid M. [VerfasserIn] |
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| Titel: | Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family |
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| Verf.angabe: | Jing-wen Lin, Patrícia Meireles, Miguel Prudêncio, Sabine Engelmann, Takeshi Annoura, Mohammed Sajid, Séverine Chevalley-Maurel, Jai Ramesar, Carolin Nahar, Cristina M.C. Avramut, Abraham J. Koster, Kai Matuschewski, Andrew P. Waters, Chris J. Janse, Gunnar R. Mair and Shahid M. Khan |
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| E-Jahr: | 2013 |
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| Jahr: | 12 March 2013 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 08.03.2022 |
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| Titel Quelle: | Enthalten in: Molecular microbiology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1987 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 88(2013), 2 vom: Apr., Seite 318-338 |
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| ISSN Quelle: | 1365-2958 |
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| Abstract: | Rhomboid-like proteases cleave membrane-anchored proteins within their transmembrane domains. In apicomplexan parasites substrates include molecules that function in parasite motility and host cell invasion. While two Plasmodium rhomboids, ROM1 and ROM4, have been examined, the roles of the remaining six rhomboids during the malaria parasite's life cycle are unknown. We present systematic gene deletion analyses of all eight Plasmodium rhomboid-like proteins as a means to discover stage-specific phenotypes and potential functions in the rodent malaria model, P. berghei. Four rhomboids (ROM4, 6, 7 and 8) are refractory to gene deletion, suggesting an essential role during asexual blood stage development. In contrast ROM1, 3, 9 and 10 were dispensable for blood stage development and exhibited no, subtle or severe defects in mosquito or liver development. Parasites lacking ROM9 and ROM10 showed no major phenotypic defects. Parasites lacking ROM1 presented a delay in blood stage patency following liver infection, but in contrast to a previous study blood stage parasites had similar growth and virulence characteristics as wild type parasites. Parasites lacking ROM3 in mosquitoes readily established oocysts but failed to produce sporozoites. ROM3 is the first apicomplexan rhomboid identified to play a vital role in sporogony. |
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| DOI: | doi:10.1111/mmi.12187 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/mmi.12187 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/mmi.12187 |
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| | DOI: https://doi.org/10.1111/mmi.12187 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1794981586 |
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| Verknüpfungen: | → Zeitschrift |
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Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family / Lin, Jing-wen [VerfasserIn]; 12 March 2013 (Online-Ressource)
