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Verfasst von:Welzel, Grit [VerfasserIn]   i
 Steinvorth, Sarah [VerfasserIn]   i
 Wenz, Frederik [VerfasserIn]   i
Titel:Cognitive effects of chemotherapy and/or cranial irradiation in adults
Paralleltitel:Kognitive Leistungsfähigkeit von Erwachsenen nach Chemo- und/oder kranieller Strahlentherapie
Verf.angabe:Grit Welzel, Sarah Steinvorth, Frederik Wenz
Jahr:2005
Umfang:16 S.
Fussnoten:Gesehen am 09.03.2022
Titel Quelle:Enthalten in: Strahlentherapie und Onkologie
Ort Quelle:Berlin : Springer Medizin, 1997
Jahr Quelle:2005
Band/Heft Quelle:181(2005), 3, Seite 141-156
ISSN Quelle:1439-099X
Abstract:Background: Cognitive effects after cranial radiotherapy are widely discussed, but there is growing evidence that chemotherapy may also induce changes in neuropsychological functioning. This review summarizes the published literature regarding cognitive functioning after cancer therapy in adult patients. Material and Methods: 63 reports from January 1980 to July 2003 assessing objective cognitive effects of irradiation and/or chemotherapy by neuropsychologic evaluation were analyzed. 57 studies with 3,424 patients were included for evaluation. Results: The results of this review confirm that both chemotherapy and irradiation can result in cognitive deficits. No clinically relevant differences are found for cognitive deficits, cognitive impairment rate, and single cognitive domains, when chemotherapy, cranial irradiation and combined radio- and chemotherapy were compared. Only 28 trials with 1,000 patients report quantitative data on patients with cognitive deficits after therapy. There are 44.1% (range 18-75%) of 451 patients in the chemotherapy group, 44.0% (range 29-83%) of 320 patients in the radiotherapy group, and 64.5% (range 30-100%) of 229 patients in the combined irradiation and chemotherapy group with cognitive deficits. Furthermore, cognitive functioning below average before chemo- or radiotherapy is found in subgroups of cancer patients. Conclusion: There is evidence of cognitive impairment in adult tumor patients after chemotherapy similar to effects after cranial irradiation. Cognitive functioning below average before therapy may be due to paraneoplastic effects. More prospective studies with,a Long-term follow-up using standardized neuropsychometric testing, assessment of premorbid intelligence, and suited control groups are needed.
DOI:doi:10.1007/s00066-005-1351-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00066-005-1351-5
 DOI: https://doi.org/10.1007/s00066-005-1351-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bone-marrow transplantation
 cell lung-cancer
 central-nervous-system
 chemotherapy
 cognitive functions
 long-term survivors
 low-grade gliomas
 nasopharyngeal carcinoma
 neuropsychology
 quality-of-life
 radiation-therapy
 radiotherapy
 total-body irradiation
 whole-brain irradiation
K10plus-PPN:179510791X
Verknüpfungen:→ Zeitschrift

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