| |  Online-Ressource |
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| Verfasst von: | Behr, Björn [VerfasserIn]  |
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| | Sorkin, Michael [VerfasserIn] |
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| | Manu, Alina [VerfasserIn] |
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| | Lehnhardt, Marcus [VerfasserIn] |
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| | Longaker, Michael T. [VerfasserIn] |
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| | Quarto, Natalina [VerfasserIn] |
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| Titel: | Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair |
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| Verf.angabe: | Björn Behr, Michael Sorkin, Alina Manu, Marcus Lehnhardt, Michael T. Longaker, and Natalina Quarto |
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| E-Jahr: | 2011 |
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| Jahr: | 26 May 2011 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 10.03.2022 |
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| Titel Quelle: | Enthalten in: Tissue engineering / A |
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| Ort Quelle: | Larchmont, NY : Liebert, 2008 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 17(2011), 15/16 vom: Aug., Seite 2061-2069 |
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| ISSN Quelle: | 1937-335X |
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| Abstract: | Bone regeneration is a complex event that requires the interaction of numerous growth factors. Fibroblast growth factor (Fgf)-ligands have been previously described for their importance in osteogenesis during development. In the current study, we investigated the role of Fgf-18 during bone regeneration. By utilizing a unicortical tibial defect model, we revealed that mice haploinsufficient for Fgf-18 have a markedly reduced healing capacity as compared with wild-type mice. Reduced levels of Runx2 and Osteocalcin but not Vegfa accompanied the impaired bone regeneration. Interestingly, our data indicated that upon injury angiogenesis was not impaired in Fgf-18+/− mice. Moreover, other Fgf-ligands and Bmp-2 could not compensate for the loss of Fgf-18. Finally, application of FGF-18 protein was able to rescue the impaired healing in Fgf-18+/− mice. Thus, we identified Fgf-18 as an important mediator of bone regeneration, which is required during later stages of bone regeneration. This study provides hints on how to engineering efficiently programmed bony tissue for long bone repair. |
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| DOI: | doi:10.1089/ten.tea.2010.0719 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1089/ten.tea.2010.0719 |
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| | Volltext: https://www.liebertpub.com/doi/10.1089/ten.tea.2010.0719 |
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| | DOI: https://doi.org/10.1089/ten.tea.2010.0719 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1795308125 |
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| Verknüpfungen: | → Zeitschrift |
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Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair / Behr, Björn [VerfasserIn]; 26 May 2011 (Online-Ressource)
