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Verfasst von:Haas, Stephan [VerfasserIn]   i
 Abbatista, Monica [VerfasserIn]   i
 Brade, Joachim [VerfasserIn]   i
 Singer, Manfred V. [VerfasserIn]   i
 Böcker, Ulrich [VerfasserIn]   i
Titel:Interleukin-18 serum levels in inflammatory bowel diseases
Titelzusatz:correlation with disease activity and inflammatory markers
Verf.angabe:Stephan L. Haas, Monica Abbatista, Joachim Brade, Manfred V. Singer, Ulrich Böcker
E-Jahr:2009
Jahr:07.03.2009
Umfang:6 S.
Fussnoten:Gesehen am 11.03.2022 ; DOI funktioniert nicht
Titel Quelle:Enthalten in: Swiss medical weekly
Ort Quelle:Basel : EMH Schweizerischer Ärzteverl., 1996
Jahr Quelle:2009
Band/Heft Quelle:139(2009), 9/10, Seite 140-145
ISSN Quelle:1424-3997
Abstract:BACKGROUND: An imbalance of cytokines is believed to contribute to the immunopathogenesis of inflammatory bowel diseases (IBD). Serum cytokine levels may correlate with disease activity and acute phase reactivity. - AIM: To determine the correlation of systemic interleukin-18 (IL-18) levels with disease activity and other markers of inflammation using a crosssectional pilot study in outpatients with IBD. - METHODS: Peripheral venous blood was obtained from 84 patients with Crohn's disease (CD) and from 46 patients with ulcerative colitis (UC). Serum levels of C-reactive protein (CRP), IL-8, IFN-gamma, IL-12p70 and IL-18 were assessed by ELISA. Disease activity was expressed by the Crohn's Disease Activity Index (CDAI) and the Clinical Activity Index (CAI), respectively. Statistical analysis comprised correlation coefficients and linear regression analysis. - RESULTS: In CD IL-18 and other cytokine concentrations, CRP levels, leukocyte and platelet counts did not correlate with the CDAI. However, IL-18 as well as IL-8 and platelets positively correlated with CRP levels (p <0.001), while IFN-gamma and IL-12p70 did not. In contrast, in UC only the CAI and CRP levels showed a significant positive correlation. COMCLUSIONS: In CD IL-18 lacks significant correlation with the CDAI, as do serum acute phase protein and other cytokine markers of inflammation. As opposed to UC, IL-18 and IL-8 may, however, serve as indicators of acute phase reactivity in CD and should be explored in a larger study.
DOI:doi:10.4414/smw.2009.12482
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.4414/smw.2009.12482
 Volltext: https://smw.ch/article/doi/smw.2009.12482
 DOI: https://doi.org/10.4414/smw.2009.12482
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 Aged
 Biomarkers
 Blood Cell Count
 Disease Progression
 Enzyme-Linked Immunosorbent Assay
 Female
 Humans
 Inflammation
 Inflammatory Bowel Diseases
 Interleukin-18
 Male
 Middle Aged
 Prognosis
 Retrospective Studies
 Young Adult
K10plus-PPN:1795337931
Verknüpfungen:→ Zeitung

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