Objective and subjective changes in patients with Peyronie's disease after management with shockwave therapy

• Verfasst von: Michel, Maurice Stephan [VerfasserIn]
• Verfasst von: Ptashnyk, Taras [VerfasserIn]
• Verfasst von: Musial, Anton [VerfasserIn]
• Verfasst von: Braun, Peter-Martin [VerfasserIn]
• Verfasst von: Lenz, Sylvia T. [VerfasserIn]
• Verfasst von: Alken, Peter [VerfasserIn]
• Verfasst von: Köhrmann, Kai-Uwe [VerfasserIn]
• Titel: Objective and subjective changes in patients with Peyronie's disease after management with shockwave therapy
• Verf.angabe: Maurice Stephan Michel, M.D, Ph.D., Taras Ptashnyk, M.D., Anton Musial, M.D., Peter Braun, M.D., Sylvia Tamara Lenz, M.Sc., Peter Alken, M.D., and Kai Uwe Köhrmann, M.D.
• Jahr: 2003
• Umfang: 4 S.
• Fussnoten: Published Online: 6 Jul 2004 ; Gesehen am 11.03.2022
• Titel Quelle: Enthalten in: Journal of endourology
• Ort Quelle: Larchmont, NY : Liebert, 1999
• Jahr Quelle: 2003
• Band/Heft Quelle: 17(2003), 1, Seite 41-44
• ISSN Quelle: 1557-900X
• DOI: doi:10.1089/089277903321196788
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1795466294

Abstract

Background and Purpose: Very few reports have been published on the management of Peyronie's disease by shockwave therapy. Existing publications on this topic are based on subjective improvement described by the patients themselves. Our aim was to determine objectively the effect of shockwave therapy on the signs and symptoms caused by Peyronie's disease. - - Patients and Methods: To date, 65 patients (age 58.4 ± 8.7 years) have been enrolled in a therapeutic pilot study. The disease duration was 33.7 ± 42.9 months. Inclusion criteria were palpable plaque together with deviation, pain (visual pain scale), or loss of distal rigidity. Clinical examination (prior to first therapy and 1, 6, and 18 months after last shockwave delivery) included palpation and sonography of the plaque (mean surface size 2.2 ± 1.1 cm2), measurement of deviation, assessment of pain and distal loss of rigidity (artificial erection induced by intracavernosal injection of 5 μg of alprostadil [Caverject]). Shockwaves (1000 impulses at 12 kV per square centimeter of plaque) were delivered to the nonerect penis once a week for a period of 5 weeks with the Minilith; Storz Medical. - - Results: Eighteen months (N = 35) after the last shockwave session, the deviation angle had decreased from 59.3° ± 38.1° to 49.3° ± 32.5° (N = 24; P = 0.1496). Pain during erection disappeared in 15 of 17 patients and was reduced in 1 other patient (P < 0.0001). There was no effect on distal rigidity in any patient. Six patients achieved satisfactory sexual intercourse (vaginal penetration) before and 15 patients after shockwave therapy. The adverse effects were small skin hematomas in 90% of patients and initial transient macrohematuria in 30%. - - Conclusion: Our study demonstrates objective and subjective changes in patients with Peyronie's disease after shockwave therapy. Artificial erection served as a control to assess improvement of the deviation angle.