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| Verfasst von: | Chan, Joseph M. [VerfasserIn]  |
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| | Quintanal-Villalonga, Álvaro [VerfasserIn] |
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| | Gao, Vianne Ran [VerfasserIn] |
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| | Xie, Yubin [VerfasserIn] |
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| | Allaj, Viola [VerfasserIn] |
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| | Chaudhary, Ojasvi [VerfasserIn] |
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| | Masilionis, Ignas [VerfasserIn] |
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| | Egger, Jacklynn [VerfasserIn] |
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| | Chow, Andrew [VerfasserIn] |
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| | Walle, Thomas [VerfasserIn] |
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| | Mattar, Marissa [VerfasserIn] |
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| | Yarlagadda, Dig V. K. [VerfasserIn] |
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| | Wang, James L. [VerfasserIn] |
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| | Uddin, Fathema [VerfasserIn] |
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| | Offin, Michael [VerfasserIn] |
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| | Ciampricotti, Metamia [VerfasserIn] |
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| | Qeriqi, Besnik [VerfasserIn] |
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| | Bahr, Amber [VerfasserIn] |
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| | de Stanchina, Elisa [VerfasserIn] |
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| | Bhanot, Umesh K. [VerfasserIn] |
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| | Lai, W. Victoria [VerfasserIn] |
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| | Bott, Matthew J. [VerfasserIn] |
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| | Jones, David R. [VerfasserIn] |
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| | Ruiz, Arvin [VerfasserIn] |
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| | Baine, Marina K. [VerfasserIn] |
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| | Li, Yanyun [VerfasserIn] |
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| | Rekhtman, Natasha [VerfasserIn] |
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| | Poirier, John T. [VerfasserIn] |
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| | Nawy, Tal [VerfasserIn] |
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| | Sen, Triparna [VerfasserIn] |
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| | Mazutis, Linas [VerfasserIn] |
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| | Hollmann, Travis J. [VerfasserIn] |
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| | Pe'er, Dana [VerfasserIn] |
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| | Rudin, Charles M. [VerfasserIn] |
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| Titel: | Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer |
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| Verf.angabe: | Joseph M. Chan, Álvaro Quintanal-Villalonga, Vianne Ran Gao, Yubin Xie, Viola Allaj, Ojasvi Chaudhary, Ignas Masilionis, Jacklynn Egger, Andrew Chow, Thomas Walle, Marissa Mattar, Dig V. K. Yarlagadda, James L. Wang, Fathema Uddin, Michael Offin, Metamia Ciampricotti, Besnik Qeriqi, Amber Bahr, Elisa de Stanchina, Umesh K. Bhanot, W. Victoria Lai, Matthew J. Bott, David R. Jones, Arvin Ruiz, Marina K. Baine, Yanyun Li, Natasha Rekhtman, John T. Poirier, Tal Nawy, Triparna Sen, Linas Mazutis, Travis J. Hollmann, Dana Pe'er and Charles M. Rudin |
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| E-Jahr: | 2021 |
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| Jahr: | 14 October 2021 |
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| Umfang: | 36 S. |
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| Fussnoten: | Gesehen am 15.03.2022 |
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| Titel Quelle: | Enthalten in: Cancer cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2002 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 39(2021,11) Seite 1479-1496, e1-e18, 36 Seiten |
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| ISSN Quelle: | 1878-3686 |
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| Abstract: | Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 SCLC transcriptomes. We observe greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes. We discover a PLCG2-high SCLC phenotype with stem-like, pro-metastatic features that recurs across subtypes and predicts worse overall survival. SCLC exhibits greater immune sequestration and less immune infiltration than lung adenocarcinoma, and SCLC-N shows less immune infiltrate and greater T cell dysfunction than SCLC-A. We identify a profibrotic, immunosuppressive monocyte/macrophage population in SCLC tumors that is particularly associated with the recurrent, PLCG2-high subpopulation. |
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| DOI: | doi:10.1016/j.ccell.2021.09.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ccell.2021.09.008 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1535610821004979 |
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| | DOI: https://doi.org/10.1016/j.ccell.2021.09.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | metastasis |
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| | myeloid |
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| | PLCG2 |
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| | SCLC |
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| | scRNA-seq |
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| | single cell |
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| | tumor atlas |
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| K10plus-PPN: | 179555214X |
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| Verknüpfungen: | → Zeitschrift |
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Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer / Chan, Joseph M. [VerfasserIn]; 14 October 2021 (Online-Ressource)
