Basic symptoms and gray matter volumes of patients at clinical high risk for psychosis

• Verfasst von: Hubl, Daniela [VerfasserIn]
• Verfasst von: Michel, Chantal [VerfasserIn]
• Verfasst von: Schultze-Lutter, Frauke [VerfasserIn]
• Verfasst von: Hauf, Martinus [VerfasserIn]
• Verfasst von: Schimmelmann, Benno [VerfasserIn]
• Verfasst von: Kaess, Michael [VerfasserIn]
• Verfasst von: Kindler, Jochen [VerfasserIn]
• Titel: Basic symptoms and gray matter volumes of patients at clinical high risk for psychosis
• Verf.angabe: Daniela Hubl, Chantal Michel, Frauke Schultze-Lutter, Martinus Hauf, Benno G. Schimmelmann, Michael Kaess and Jochen Kindler
• Jahr: 2021
• Umfang: 9 S.
• Fussnoten: First published online: 14 May 2020 ; Gesehen am 04.05.2022
• Titel Quelle: Enthalten in: Psychological medicine
• Ort Quelle: Cambridge : Cambridge Univ. Press, 1970
• Jahr Quelle: 2021
• Band/Heft Quelle: 51(2021), 15, Seite 2666-2674
• ISSN Quelle: 1469-8978
• DOI: doi:10.1017/S0033291720001282
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Basic symptoms
• Sach-SW: first-episode psychosis
• Sach-SW: gray matter volume
• Sach-SW: psychosis risk
• Sach-SW: ultra-high risk
• K10plus-PPN: 1795573996

Abstract

Background - Clinical high-risk (CHR) for psychosis is indicated by ultra-high risk (UHR) and basic symptom (BS) criteria; however, conversion rates are highest when both UHR and BS criteria are fulfilled (UHR&BS). While BSs are considered the most immediate expression of neurobiological aberrations underlying the development of psychosis, research on neurobiological correlates of BS is scarce. - - Methods - We investigated gray matter volumes (GMV) of 20 regions of interest (ROI) previously associated with UHR criteria in 90 patients from the Bern early detection service: clinical controls (CC), first-episode psychosis (FEP), UHR, BS and UHR&BS. We expected lowest GMV in FEP and UHR&BS, and highest volume in CC with UHR and BS in-between. - - Results - Significantly, lower GMV was detected in FEP and UHR&BS patients relative to CC with no other significant between-group differences. When ROIs were analyzed separately, seven showed a significant group effect (FDR corrected), with five (inferior parietal, medial orbitofrontal, lateral occipital, middle temporal, precuneus) showing significantly lower GM volume in the FEP and/or UHR&BS groups than in the CC group (Bonferroni corrected). In the CHR group, only COGDIS scores correlated negatively with cortical volumes. - - Conclusions - This is the first study to demonstrate that patients who fulfill both UHR and BS criteria - a population that has been associated with higher conversion rates - exhibit more severe GMV reductions relative to those who satisfy BS or UHR criteria alone. This result was mediated by the BS in the UHR&BS group, as only the severity of BS was linked to GMV reductions.