Status: Bibliographieeintrag
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| Verfasst von: | Feick, Peter [VerfasserIn]  |
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| | Haas, Stephan [VerfasserIn] |
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| | Singer, Manfred V. [VerfasserIn] |
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| | Böcker, Ulrich [VerfasserIn] |
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| Titel: | Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin |
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| Verf.angabe: | Peter Feick, Stephan R.L. Haas, Manfred V. Singer, Ulrich Böcker |
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| Jahr: | 2006 |
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| Umfang: | 13 S. |
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| Fussnoten: | Available online 13 December 2005 ; Gesehen am 17.03.2022 |
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| Titel Quelle: | Enthalten in: Toxicology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1973 |
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| Jahr Quelle: | 2006 |
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| Band/Heft Quelle: | 219(2006), 1/3 vom: 15. Feb., Seite 60-72 |
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| ISSN Quelle: | 1879-3185 |
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| Abstract: | We investigated the potential pathophysiological role of non-lethal formaldehyde concentrations on human intestinal epithelial HT-29 cells. Expression levels of actin, tubulin and detectable cytokeratin isoforms 5, 13, 18, 19 and 20 were not affected after 24h of exposure to 1mM formaldehyde. By contrast, cellular organization of cytoskeletal constituents was already changed after 60min. Within 15min, formaldehyde induced profound tyrosine phosphorylation of the focal adhesion protein paxillin and of proteins at about 120-130kDa. Concomitantly, phosphorylation of ERK-1/2 and p38 MAP kinase occurred. Paxillin was not only tyrosine phosphorylated but underwent a sustained molecular weight shift representing serine/threonine phosphorylation that was independent of MAP kinase activity and EGF-R-mediated signalling. Our data show that exposure of intestinal epithelial cells to low-dose formaldehyde is followed by rapid and profound signalling events. The data suggest a modifier role of environmental or endogenous formaldehyde for epithelial cell functions. |
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| DOI: | doi:10.1016/j.tox.2005.11.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.tox.2005.11.004 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0300483X05005378 |
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| | DOI: https://doi.org/10.1016/j.tox.2005.11.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Formaldehyde |
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| | Intestinal epithelial cell |
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| | MAP kinase |
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| | Paxillin |
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| K10plus-PPN: | 1795839503 |
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| Verknüpfungen: | → Zeitschrift |
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Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin / Feick, Peter [VerfasserIn]; 2006 (Online-Ressource)
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