Technical characterization of an ultrasound source for noninvasive thermoablation by high-intensity focused ultrasound

• Verfasst von: Köhrmann, Kai-Uwe [VerfasserIn]
• Verfasst von: Michel, Maurice Stephan [VerfasserIn]
• Verfasst von: Steidler, Annette [VerfasserIn]
• Verfasst von: Marlinghaus, Ernst H. [VerfasserIn]
• Verfasst von: Kraut, Oliver [VerfasserIn]
• Verfasst von: Alken, Peter [VerfasserIn]
• Titel: Technical characterization of an ultrasound source for noninvasive thermoablation by high-intensity focused ultrasound
• Verf.angabe: K.U. Köhrmann, M.S. Michel, A. Steidler, E. Marlinghaus, O. Kraut, P. Alken
• E-Jahr: 2002
• Jahr: 19 July 2002
• Umfang: 5 S.
• Fussnoten: Gesehen am 17.03.2022
• Titel Quelle: Enthalten in: BJU international
• Ort Quelle: Oxford : Wiley-Blackwell, 1999
• Jahr Quelle: 2002
• Band/Heft Quelle: 90(2002), 3, Seite 248-252
• ISSN Quelle: 1464-410X
• DOI: doi:10.1046/j.1464-410X.2002.02848.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ex-vivo model
• Sach-SW: high-intensity focused ultrasound
• Sach-SW: noninvasive thermal ablation
• Sach-SW: sound intensity
• Sach-SW: tissue necrosis
• K10plus-PPN: 1795973862

Abstract

Objective To develop a generator for high-intensity focused ultrasound (HIFU, a method of delivering ultrasonic energy with resultant heat and tissue destruction to a tight focus at a selected depth within the body), designed for extracorporeal coupling to allow various parenchymal organs to be treated. Material and methods The ultrasound generated by a cylindrical piezo-ceramic element is focused at a depth of 10 cm using a parabolic reflector with a diameter of 10 cm. A diagnostic B-mode ultrasonographic transducer is integrated into the source to allow the focus to be located in the target area. The field distribution of the sound pressure was measured in degassed water using a needle hydrophone. An ultrasound-force balance was used to determine the acoustic power. These measurements allowed the spatially averaged sound intensity to be calculated. The morphology and extent of tissue necrosis induced by HIFU was examined on an ex-vivo kidney model. Results The two-dimensional field distribution resulted in an approximately ellipsoidal focus of 32×4 mm (− 6 dB). The spatially maximum averaged sound intensity was 8591 W/cm2 at an electrical power of 400 W. The lesion caused to the ex-vivo kidney at this maximum generator power with a pulse duration of 2 s was a clearly delineated ellipsoidal coagulation necrosis up to 8.8×2.3 mm (length×width) and with central liquefied necrosis of 7.9×1.9 mm. Conclusion This newly developed ultrasound generator with a focal length of 10 cm can induce clear necrosis in parenchymal tissue. Because of its specific configuration and the available power range of the ultrasound generator, there is potential for therapeutic noninvasive ablation of tissue deep within a patient's body.