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| Verfasst von: | Linster, Eric [VerfasserIn]  |
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| | Forero Ruiz, Francy Liliana [VerfasserIn] |
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| | Miklánková, Pavlína [VerfasserIn] |
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| | Ruppert, Thomas [VerfasserIn] |
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| | Mueller, Johannes [VerfasserIn] |
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| | Armbruster, Laura [VerfasserIn] |
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| | Gong, Xiaodi [VerfasserIn] |
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| | Serino, Giovanna [VerfasserIn] |
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| | Mann, Matthias [VerfasserIn] |
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| | Hell, Rüdiger [VerfasserIn] |
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| | Wirtz, Markus [VerfasserIn] |
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| Titel: | Cotranslational N-degron masking by acetylation promotes proteome stability in plants |
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| Verf.angabe: | Eric Linster, Francy L. Forero Ruiz, Pavlina Miklankova, Thomas Ruppert, Johannes Mueller, Laura Armbruster, Xiaodi Gong, Giovanna Serino, Matthias Mann, Rüdiger Hell & Markus Wirtz |
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| E-Jahr: | 2022 |
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| Jahr: | 10 February 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 30.03.2022 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), Artikel-ID 810, Seite 1-12 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | N-terminal protein acetylation (NTA) is a prevalent protein modification essential for viability in animals and plants. The dominant executor of NTA is the ribosome tethered Nα-acetyltransferase A (NatA) complex. However, the impact of NatA on protein fate is still enigmatic. Here, we demonstrate that depletion of NatA activity leads to a 4-fold increase in global protein turnover via the ubiquitin-proteasome system in Arabidopsis. Surprisingly, a concomitant increase in translation, actioned via enhanced Target-of-Rapamycin activity, is also observed, implying that defective NTA triggers feedback mechanisms to maintain steady-state protein abundance. Quantitative analysis of the proteome, the translatome, and the ubiquitome reveals that NatA substrates account for the bulk of this enhanced turnover. A targeted analysis of NatA substrate stability uncovers that NTA absence triggers protein destabilization via a previously undescribed and widely conserved nonAc/N-degron in plants. Hence, the imprinting of the proteome with acetylation marks is essential for coordinating proteome stability. |
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| DOI: | doi:10.1038/s41467-022-28414-5 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41467-022-28414-5 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-022-28414-5 |
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| | DOI: https://doi.org/10.1038/s41467-022-28414-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Plant stress responses |
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| | Proteomics |
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| | Ubiquitylation |
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| K10plus-PPN: | 1796012475 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Cotranslational N-degron masking by acetylation promotes proteome stability in plants / Linster, Eric [VerfasserIn]; 10 February 2022 (Online-Ressource)
