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Verfasst von:Weidner, Artur [VerfasserIn]   i
 Stengl, Christina [VerfasserIn]   i
 Dinkelbach, Fabian [VerfasserIn]   i
 Dorsch, Stefan [VerfasserIn]   i
 Murillo, Carlos [VerfasserIn]   i
 Seeber, Steffen [VerfasserIn]   i
 Gnirs, Regula [VerfasserIn]   i
 Runz, Armin [VerfasserIn]   i
 Echner, Gernot [VerfasserIn]   i
 Karger, Christian [VerfasserIn]   i
 Jäkel, Oliver [VerfasserIn]   i
Titel:An abdominal phantom with anthropomorphic organ motion and multimodal imaging contrast for MR-guided radiotherapy
Verf.angabe:Artur Weidner, Christina Stengl, Fabian Dinkel, Stefan Dorsch, Carlos Murillo, Steffen Seeber, Regula Gnirs, Armin Runz, Gernot Echner, Christian P Karger and Oliver Jäkel
E-Jahr:2022
Jahr:11 February 2022
Umfang:10 S.
Fussnoten:Gesehen am 18.03.2022
Titel Quelle:Enthalten in: Physics in medicine and biology
Ort Quelle:Bristol : IOP Publ., 1956
Jahr Quelle:2022
Band/Heft Quelle:67(2022), 4, Artikel-ID 045009, Seite 1-10
ISSN Quelle:1361-6560
Abstract:Purpose. Improvements in image-guided radiotherapy (IGRT) enable accurate and precise treatment of moving tumors in the abdomen while simultaneously sparing healthy tissue. However, the lack of validation tools for newly developed MR-guided radiotherapy hybrid devices such as the MR-Linac is an open issue. This study presents a custom developed abdominal phantom with respiratory organ motion and multimodal imaging contrast to perform end-to-end tests for IGRT treatment planning scenarios. Methods. The abdominal phantom contains deformable and anatomically shaped liver and kidney models made of Ni-DTPA and KCl-doped agarose mixtures that can be reproducibly positioned within the phantom. Organ models are wrapped in foil to avoid ion exchange with the surrounding agarose and to provide stable T1 and T2 relaxation times as well as HU numbers. Breathing motion is realized by a diaphragm connected to an actuator that is hydraulically controlled via a programmable logic controller. With this system, artificial and patient-specific breathing patterns can be carried out. In 1.5 T magnetic resonance imaging (MRI), diaphragm, liver and kidney motion was measured and compared to the breathing motion of a healthy male volunteer for different breathing amplitudes including shallow, normal and deep breathing. Results. The constructed abdominal phantom demonstrated organ-equivalent intensity values in CT as well as in MRI. T1-weighted (T1w) and T2-weighted (T2w) relaxation times for 1.5 T and CT numbers were 552.9 ms, 48.2 ms and 48.8 HU (liver) as well as 950.42 ms, 79 ms and 28.2 HU (kidney), respectively. These values were stable for more than six months. Extracted breathing motion from a healthy volunteer revealed a liver to diaphragm motion ratio (LDMR) of 64.4% and a kidney to diaphragm motion ratio (KDMR) of 30.7%. Well-comparable values were obtained for the phantom (LDMR: 65.5%, KDMR: 27.5%). Conclusions. The abdominal phantom demonstrated anthropomorphic T1 and T2 relaxation times as well as HU numbers and physiological motion pattern in MRI and CT. This allows for wide use in the validation of IGRT including MRgRT.
DOI:doi:10.1088/1361-6560/ac4ef8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1088/1361-6560/ac4ef8
 DOI: https://doi.org/10.1088/1361-6560/ac4ef8
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1796014850
Verknüpfungen:→ Zeitschrift

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