| |  Online-Ressource |
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| Verfasst von: | Bunse, Lukas [VerfasserIn]  |
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| | Sommerer, Claudia [VerfasserIn] |
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| | Tan, Chin Leng [VerfasserIn] |
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| | Korell, Felix [VerfasserIn] |
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| | Schmitt, Anita [VerfasserIn] |
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| | Hückelhoven-Krauss, Angela [VerfasserIn] |
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| | Neuber, Brigitte [VerfasserIn] |
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| | Mertens, Thomas [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Green, Edward W. [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| Titel: | Common T-cell-receptor motifs and features in patients with cytomegalovirus (CMV)-seronegative end-stage renal disease receiving a peptide caccination against CMV |
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| Verf.angabe: | Lukas Bunse, Claudia Sommerer, Chin Leng Tan, Felix Korell, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Thomas Mertens, Michael Platten, Edward W. Green, Martin Zeier and Michael Schmitt |
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| E-Jahr: | 2022 |
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| Jahr: | 18 January 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 30.03.2022 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 3, Artikel-ID 1029, Seite 1-12 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | After solid-organ transplantation, reactivation of the cytomegalovirus (CMV) is often observed in seronegative patients and associated with a high risk of disease and mortality. CMV-specific T cells can prevent CMV reactivation. In a phase 1 trial, CMV-seronegative patients with end-stage renal disease listed for kidney transplantation were subjected to CMV phosphoprotein 65 (CMVpp65) peptide vaccination and further investigated for T-cell responses. To this end, CMV-specific CD8+ T cells were characterized by bulk T-cell-receptor (TCR) repertoire sequencing and combined single-cell RNA and TCR sequencing. In patients mounting an immune response to the vaccine, a common SYE(N)E TCR motif known to bind CMVpp65 was detected. CMV-peptide-vaccination-responder patients had TCR features distinct from those of non-responders. In a non-responder patient, a monoclonal inflammatory T-cell response was detected upon CMV reactivation. The identification of vaccine-induced CMV-reactive TCRs motifs might facilitate the development of cellular therapies for patients wait-listed for kidney transplantation. |
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| DOI: | doi:10.3390/ijms23031029 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms23031029 |
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| | Volltext: https://www.mdpi.com/1422-0067/23/3/1029 |
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| | DOI: https://doi.org/10.3390/ijms23031029 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CMV |
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| | end-stage renal disease |
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| | peptide vaccination |
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| | single-cell sequencing |
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| | TCR motif |
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| K10plus-PPN: | 1796134007 |
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| Verknüpfungen: | → Zeitschrift |
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Common T-cell-receptor motifs and features in patients with cytomegalovirus (CMV)-seronegative end-stage renal disease receiving a peptide caccination against CMV / Bunse, Lukas [VerfasserIn]; 18 January 2022 (Online-Ressource)
