Neurobehavioral toxicity of total body irradiation

• Verfasst von: Peper, Martin [VerfasserIn]
• Verfasst von: Steinvorth, Sarah [VerfasserIn]
• Verfasst von: Schraube, Peter [VerfasserIn]
• Verfasst von: Frühauf, Stefan [VerfasserIn]
• Verfasst von: Haas, Rainer [VerfasserIn]
• Verfasst von: Kimmig, Bernhard [VerfasserIn]
• Verfasst von: Lohr, Frank [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Wannenmacher, Michael [VerfasserIn]
• Titel: Neurobehavioral toxicity of total body irradiation
• Titelzusatz: a follow-up in long-term survivors
• Verf.angabe: Martin Peper, Sarah Steinvorth, Peter Schraube, Stefan Fruehauf, Rainer Haas, Bernhard N. Kimmig, Frank Lohr, Frederik Wenz, Michael Wannenmacher
• E-Jahr: 2000
• Jahr: 27 January 2000
• Umfang: 9 S.
• Fussnoten: Gesehen am 22.03.2022
• Titel Quelle: Enthalten in: International journal of radiation oncology, biology, physics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2000
• Band/Heft Quelle: 46(2000), 2, Seite 303-311
• ISSN Quelle: 1879-355X
• DOI: doi:10.1016/S0360-3016(99)00442-3
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Behavioral toxicity
• Sach-SW: Bone marrow transplant
• Sach-SW: Neuropsychology
• Sach-SW: Radiotherapy
• Sach-SW: Total body irradiation
• K10plus-PPN: 1796263834

Abstract

Purpose: Total body irradiation (TBI) in preparation for bone marrow transplantation (BMT) is a routine treatment of hematological malignancy. A retrospective and a prospective group study of long-term cerebral side effects was performed, with a special emphasis on neurobehavioral toxicity effects. Methods and Materials: Twenty disease-free patients treated with hyperfractionated TBI (14.4 Gy, 12 × 1.2 Gy, 4 days), 50 mg/kg cyclophosphamide, and autologous BMT (mean age 38 years, range 17-52 years; age at TBI 35 years, 16-50 years; follow-up time 32 months, 9-65 months) participated in a neuropsychological, neuroradiological, and neurological examination. Data were compared to 14 patients who were investigated prior to TBI. Eleven patients with renal insufficiencies matched for sex and age (38 years, 20-52 years) served as controls. In a longitudinal approach, neuropsychological follow-up data were assessed in 12 long-term survivors (45 years, 23-59 years; follow-up time 8.8 years, 7-10.8 years; time since diagnosis 10.1 years, 7.5-14.2 years). Results: No evidence of neurological deficits was found in post-TBI patients except one case of peripheral movement disorder of unknown origin. Some patients showed moderate brain atrophy. Neuropsychological assessment showed a subtle reduction of memory performance of about one standard deviation. Cognitive decline in individual patients appeared to be associated with pretreatment (brain irradiation, intrathecal methotrexate). Ten-years post disease onset, survivors without pretreatment showed behavioral improvement up to the premorbid level. Conclusion: The incidence of long-term neurobehavioral toxicity was very low for the present TBI/BMT regimen.