| |  Online-Ressource |
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| Verfasst von: | Gaab, Christine [VerfasserIn]  |
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| | Adolph, Jonas E. [VerfasserIn] |
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| | Tippelt, Stephan [VerfasserIn] |
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| | Mikasch, Ruth [VerfasserIn] |
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| | Obrecht, Denise [VerfasserIn] |
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| | Mynarek, Martin [VerfasserIn] |
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| | Rutkowski, Stefan [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Milde, Till [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Bison, Brigitte [VerfasserIn] |
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| | Warmuth-Metz, Monika [VerfasserIn] |
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| | Kortmann, Rolf-Dieter [VerfasserIn] |
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| | Dietzsch, Stefan [VerfasserIn] |
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| | Pietsch, Torsten [VerfasserIn] |
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| | Timmermann, Beate [VerfasserIn] |
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| | Sträter, Ronald [VerfasserIn] |
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| | Bode, Udo [VerfasserIn] |
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| | Faldum, Andreas [VerfasserIn] |
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| | Kwiecien, Robert [VerfasserIn] |
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| | Fleischhack, Gudrun [VerfasserIn] |
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| Titel: | Local and systemic therapy of recurrent medulloblastomas in children and adolescents |
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| Titelzusatz: | results of the P-HIT-REZ 2005 study |
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| Verf.angabe: | Christine Gaab, Jonas E. Adolph, Stephan Tippelt, Ruth Mikasch, Denise Obrecht, Martin Mynarek, Stefan Rutkowski, Stefan M. Pfister, Till Milde, Olaf Witt, Brigitte Bison, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Stefan Dietzsch, Torsten Pietsch, Beate Timmermann, Ronald Sträter, Udo Bode, Andreas Faldum, Robert Kwiecien and Gudrun Fleischhack |
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| E-Jahr: | 2022 |
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| Jahr: | 18 January 2022 |
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| Umfang: | 24 S. |
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| Fussnoten: | Gesehen am 22.03.2022 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 3, Artikel-ID 471, Seite 1-24 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Recurrent medulloblastomas are associated with survival rates <10%. Adequate multimodal therapy is being discussed as having a major impact on survival. In this study, 93 patients with recurrent medulloblastoma treated in the German P-HIT-REZ 2005 Study were analyzed for survival (PFS, OS) dependent on patient, disease, and treatment characteristics. The median age at the first recurrence was 10.1 years (IQR: 6.9-16.1). Median PFS and OS, at first recurrence, were 7.9 months (CI: 5.7-10.0) and 18.5 months (CI: 13.6-23.5), respectively. Early relapses/progressions (<18 months, n = 30/93) found mainly in molecular subgroup 3 were associated with markedly worse median PFS (HR: 2.34) and OS (HR: 3.26) in regression analyses. A significant survival advantage was found for the use of volume-reducing surgery as well as radiotherapy. Intravenous chemotherapy with carboplatin and etoposide (ivCHT, n = 28/93) showed improved PFS and OS data and the best objective response rate (ORR) was 66.7% compared to oral temozolomide (oCHT, n = 47/93) which was 34.8%. Intraventricular (n = 43) as well as high-dose chemotherapy (n = 17) at first relapse was not related to a significant survival benefit. Although the results are limited due to a non-randomized study design, they may serve as a basis for future treatment decisions in order to improve the patients’ survival. |
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| DOI: | doi:10.3390/cancers14030471 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers14030471 |
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| | Volltext: https://www.mdpi.com/2072-6694/14/3/471 |
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| | DOI: https://doi.org/10.3390/cancers14030471 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chemotherapy |
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| | children |
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| | intraventricular therapy |
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| | medulloblastoma |
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| | radiotherapy |
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| | re-irradiation |
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| | recurrent |
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| | refractory |
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| | surgery |
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| K10plus-PPN: | 1796266582 |
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| Verknüpfungen: | → Zeitschrift |
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Local and systemic therapy of recurrent medulloblastomas in children and adolescents / Gaab, Christine [VerfasserIn]; 18 January 2022 (Online-Ressource)
