Cataract incidence after total-body irradiation

• Verfasst von: Zierhut, Dietmar [VerfasserIn]
• Verfasst von: Lohr, Frank [VerfasserIn]
• Verfasst von: Schraube, Peter [VerfasserIn]
• Verfasst von: Huber, Peter [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Haas, Rainer [VerfasserIn]
• Verfasst von: Fehrentz, Dieter [VerfasserIn]
• Verfasst von: Flentje, Michael [VerfasserIn]
• Verfasst von: Hunstein, Werner [VerfasserIn]
• Verfasst von: Wannenmacher, Michael [VerfasserIn]
• Titel: Cataract incidence after total-body irradiation
• Verf.angabe: Dietmar Zierhut, Frank Lohr, Peter Schraube, Peter Huber, Frederik Wenz, Rainer Haas, Dieter Fehrentz, Michael Flentje, Werner Hunstein, Michael Wannenmacher
• E-Jahr: 2000
• Jahr: 7 January 2000
• Umfang: 5 S.
• Fussnoten: Gesehen am 22.03.2022
• Titel Quelle: Enthalten in: International journal of radiation oncology, biology, physics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2000
• Band/Heft Quelle: 46(2000), 1, Seite 131-135
• ISSN Quelle: 1879-355X
• DOI: doi:10.1016/S0360-3016(99)00354-5
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bone marrow transplant
• Sach-SW: Cataract
• Sach-SW: Radiotherapy
• Sach-SW: Total-body irradiation (TBI)
• Sach-SW: Toxicity
• K10plus-PPN: 1796270881

Abstract

Purpose: The aim of this retrospective study was to evaluate cataract incidence in a homogeneously-treated group of patients after total-body irradiation (TBI) followed by autologous bone marrow transplantation or peripheral blood stem cell transplantation. Methods and Materials: Between 1982 and 1994, a total of 260 patients received either autologous bone marrow or blood stem cell transplantation for hematological malignancy at the University of Heidelberg. Two hundred nine of these patients received TBI in our hospital. Radiotherapy was applied as hyperfractionated TBI, with a median dose of 14.4 Gy in 12 fractions over 4 days. Minimum time between fractions was 4 h. Photons with an energy of 23 MeV were used with a dose rate of 7-18 cGy/min. Ninety-six of the 209 irradiated patients were still alive in 1996; 86 of these patients (52 men, 33 women) answered a questionnaire and could be examined ophthalmologically. The median age at time of TBI was 38.5 years, with a range of 15-59 years. Results: The median follow-up is now 5.8 years, with a range of 1.7-13 years. Cataract occurred in 28/85 patients (32.9%) after a median of 47 months (1-104 months). In 6 of 28 patients who developed a cataract, surgery of the cataract was performed. Whole-brain irradiation prior to TBI had been performed more often in the group of patients developing cataract (14.3%) versus 10.7% in the group of patients without cataract. However, there was no statistical difference (Chi-square, p > 0.05). Conclusion: Cataract is a common side effect of TBI. Cataract incidence found in our patients is comparable to results of other centers using a fractionated regimen for TBI. To assess the incidence of cataract after TBI, a long-term follow-up is required.