Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Biswas, Mithun [VerfasserIn]  |
| Voltz, Karine [VerfasserIn]  |
| Smith, Jeremy C. [VerfasserIn]  |
| Langowski, Jörg [VerfasserIn]  |
Titel: | Role of histone tails in structural stability of the nucleosome |
Verf.angabe: | Mithun Biswas, Karine Voltz, Jeremy C. Smith, Jörg Langowski |
E-Jahr: | 2011 |
Jahr: | December 15, 2011 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 24.03.2022 |
Titel Quelle: | Enthalten in: Public Library of SciencePLoS Computational Biology |
Ort Quelle: | San Francisco, Calif. : Public Library of Science, 2005 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 7(2011), 12 vom: Dez., Artikel-ID e1002279, Seite 1-12 |
ISSN Quelle: | 1553-7358 |
Abstract: | Histone tails play an important role in nucleosome structure and dynamics. Here we investigate the effect of truncation of histone tails H3, H4, H2A and H2B on nucleosome structure with 100 ns all-atom molecular dynamics simulations. Tail domains of H3 and H2B show propensity of -helics formation during the intact nucleosome simulation. On truncation of H4 or H2B tails no structural change occurs in histones. However, H3 or H2A tail truncation results in structural alterations in the histone core domain, and in both the cases the structural change occurs in the H2A3 domain. We also find that the contacts between the histone H2A C terminal docking domain and surrounding residues are destabilized upon H3 tail truncation. The relation between the present observations and corresponding experiments is discussed. |
DOI: | doi:10.1371/journal.pcbi.1002279 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pcbi.1002279 |
| Volltext: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002279 |
| DOI: https://doi.org/10.1371/journal.pcbi.1002279 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biochemical simulations |
| Crystal structure |
| Histones |
| Hydrogen bonding |
| Monomers |
| Nucleosome mapping |
| Nucleosomes |
| Protein domains |
K10plus-PPN: | 1796583324 |
Verknüpfungen: | → Zeitschrift |
Role of histone tails in structural stability of the nucleosome / Biswas, Mithun [VerfasserIn]; December 15, 2011 (Online-Ressource)
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